4,4-Difluoropiperidine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144230-52-4 |
| Product name | 4,4-Difluoropiperidine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4,4-Difluoropiperidine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4,4-Difluoropiperidine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4,4-Difluoropiperidine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing fluorinated piperidine-based drugs, used in constructing the molecular frameworks of antipsychotics, antidepressants, and related compounds | Used to construct the target molecule’s piperidine scaffold via nucleophilic substitution or reductive amination, coupling 4,4-difluoropiperidine hydrochloride with aryl halides or carbonyl compounds |
Manufacturing Quality Control of 4,4-Difluoropiperidine hydrochloride
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Characteristics | Visual Inspection | Observe the sample as a white to off-white crystalline powder, free of visible foreign matter, meeting pharmacopoeia or internal control standards. |
| Identification | Infrared Spectroscopy (IR) | Confirm characteristic absorption peaks such as C–F, N–H, and C–N by comparing with the standard spectrum (e.g., C–F stretching vibration at 1100–1200 cm⁻¹). |
| Nuclear Magnetic Resonance Hydrogen Spectrum (¹H NMR) | Determined in DMSO-d₆ or CD₃OD, confirm proton chemical shifts of the piperidine ring (δ 2.5–3.5 ppm) and coupling splitting features caused by fluorine substitution. | |
| High-Performance Liquid Chromatography (HPLC) | Compare retention time with reference substance using a C18 column, mobile phase: water-acetonitrile with 0.1% trifluoroacetic acid. | |
| Content Determination | High-Performance Liquid Chromatography with UV detection (HPLC-UV) | Determine the main component content using external standard method, wavelength selected at 210–230 nm (UV absorption), linear range 0.05–2.0 mg/mL, R² > 0.999. |
| Non-aqueous Titration | Use glacial acetic acid as solvent, perchloric acid as titrant, crystal violet as indicator, determine the free base content in hydrochloride salt, calculate purity. | |
| Moisture Content | Karl Fischer Titration | Determine moisture content using coulometric or volumetric methods, controlled at ≤0.5% (according to process requirements), ensuring stability. |
| Residual Solvents | Gas Chromatography (GC) | Determine residual solvents such as methanol, ethanol, acetone, dichloromethane according to ICH Q3C, using DB-624 column and FID detector. |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography with UV/MS detection (HPLC-UV/MS) | Separate degradation products (e.g., defluorinated product, oxidized product, dimer) using gradient elution, detection limit ≤0.1%, qualitative analysis with mass spectrometry (LC-MS) if necessary. |
| Chloride Content | Ion Chromatography (IC) or Precipitation Titration | Determine chloride concentration directly by ion chromatography (detection limit 0.01 ppm), or by silver nitrate titration, ensure compliance with stoichiometric ratio (theoretical Cl⁻ ≈ 25.5%). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine heavy metals such as lead, cadmium, mercury, arsenic, controlled at ≤10 ppm (according to ICH Q3D), suitable for final control of active pharmaceutical ingredients. |
| Particle Size Distribution | Laser Diffraction | Control particle size (e.g., D90 < 50 μm), affect solubility and consistency of formulation processes (applicable for API used in formulations). |
| Melting Point | Melting Point Apparatus | Determine melting range (usually 150–160°C), compare with literature or standard samples to judge polymorphic consistency. |
| Polymorphic Analysis | X-ray Powder Diffraction (XRPD) | Confirm crystal structure, prevent polymorphic transformation, ensure consistency of stability and solubility. |
| pH Value (Solution) | pH Meter Measurement | Determine pH value of 1% aqueous solution (typically 4.5–6.0), reflects acidic characteristics of hydrochloride salt, controls batch consistency. |
Technical Specifications of 4,4-Difluoropiperidine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 215–220 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4,4-Difluoropiperidine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4,4-Difluoropiperidine hydrochloride
Safety Information of 4,4-Difluoropiperidine hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4,4-Difluoropiperidine hydrochloride
Industrial 4,4-Difluoropiperidine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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