(R)-1-Boc-2-cyanopyrrolidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144688-70-0 |
| Product name | (R)-1-Boc-2-cyanopyrrolidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-1-Boc-2-cyanopyrrolidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-1-Boc-2-cyanopyrrolidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-1-Boc-2-cyanopyrrolidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for the synthesis of the antidiabetic drug sitagliptin | Asymmetric hydrogenation or enzymatic reduction of a key precursor, followed by deprotection and coupling to construct sitagliptin’s β-aminoamide structure |
| Pharmaceuticals | Chiral building block for DPP-4 inhibitor candidates containing a 2-cyanopyrrolidine scaffold | Used as a chiral cyclic nitrile structural unit in multistep organic synthesis, including nucleophilic addition, reductive amination, or cycloaddition |
Manufacturing Quality Control of (R)-1-Boc-2-cyanopyrrolidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase chromatography with UV detection at 210-220 nm based on peak area comparison against reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separates (R)- and (S)-enantiomers on a chiral stationary phase; ee calculated from peak area ratio of enantiomers. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., THF, toluene, ethyl acetate) using flame ionization detection after headspace or direct injection. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric titration where iodine reacts stoichiometrically with water in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) by plasma ionization and mass spectrometric detection with isotopic resolution. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Residual Boc Reagent | GC-FID | Detects and quantifies residual di-tert-butyl dicarbonate (Boc2O) by gas chromatographic separation and FID response. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., de-Boc product, hydrolyzed acid, dimer) using gradient reverse-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating crystallinity and presence of impurities. |
| Specific Optical Rotation | [alpha]D Measurement | Measures rotation of plane-polarized light at 589 nm to confirm chiral integrity and concentration-dependent specific rotation. |
| Residue on Ignition | Gravimetric Analysis | Determines non-volatile inorganic residue after controlled high-temperature ashing and weighing. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution in dry or wet dispersion mode based on angular scattering intensity of laser light. |
Technical Specifications of (R)-1-Boc-2-cyanopyrrolidine
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | [α]²⁰D = -25.0° to -31.0° (c=1.0 in CHCl₃) |
| Melting Point | 78.0–82.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-1-Boc-2-cyanopyrrolidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-1-Boc-2-cyanopyrrolidine
Packaging of (R)-1-Boc-2-cyanopyrrolidine
Industrial (R)-1-Boc-2-cyanopyrrolidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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