China Factory Direct
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| CAS number | 144701-20-2 |
| Product name | FMOC-DL-NLE-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as an amino-protecting group for N-terminal amine protection in solid-phase peptide synthesis (SPPS) | Prepared by reacting DL-norleucine with Fmoc-Cl or Fmoc-OSu in SPPS; subsequently employed for selective deprotection during peptide chain elongation |
| Biochemical Research | Used to synthesize peptide probes and bioactive molecules containing non-canonical amino acids | Employed as an Fmoc-protected non-standard amino acid building block in peptide library construction and structure–activity relationship (SAR) studies |
| Chemical Synthesis | Used as a chiral intermediate in the synthesis of complex drug molecule precursors | Introduced via Fmoc protection of the DL-norleucine scaffold for asymmetric synthesis or for purification and coupling of intermediates following chiral resolution |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 260-280 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of D- and L-enantiomers on a chiral stationary phase, with UV detection to calculate enantiomeric excess. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine-based reagent to quantify water content based on stoichiometric reaction. |
| Residual Solvents | GC-FID | Gas chromatographic separation followed by flame ionization detection to quantify common organic solvents (e.g., DMF, DCM, MeOH). |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after high-temperature incineration at 500-600 C and weighing the residual residue. |
| Appearance | Visual Inspection | Assessment of physical state, color, and homogeneity under controlled lighting against established reference standards. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs, using calibrated capillary apparatus. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength. |
| Related Substances | HPLC-UV | Identification and quantification of structurally related impurities using gradient reverse-phase HPLC with UV detection. |
| pH (1% w/v aqueous suspension) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous suspension using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution based on angular dependence of laser light scattering from dispersed sample. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 138°C - 142°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | -1.0° to +1.0° (c=1, in DMF) |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.