FMoc-DL-proline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144829-96-9 |
| Product name | FMoc-DL-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for FMoc-DL-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMoc-DL-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMoc-DL-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral protected amino acid monomers for solid-phase peptide synthesis (SPPS) | Used as N-α-Fmoc-protected DL-proline in peptide chain elongation; the Fmoc group is selectively removed under basic conditions (e.g., piperidine/DMF) to enable sequential coupling; the DL configuration is employed primarily in diastereoselectivity studies or synthesis of specific racemic model peptides |
| Organic Synthesis | Chiral auxiliaries and structural modification intermediates | Applied in asymmetric catalysis, cyclization reactions, or as a proline derivative for constructing heterocyclic scaffolds; the Fmoc group provides orthogonal protection, facilitating subsequent functional group transformations and deprotection |
| Biochemical Research | Raw material for synthesizing peptide probes and labeling reagents | Used to prepare proline-containing fluorescently labeled peptides, biotinylated peptides, or stable isotope-labeled peptides for experiments on protein–protein interactions, enzyme substrate specificity, and conformational analysis |
Manufacturing Quality Control of FMoc-DL-proline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 268 nm. |
| Chiral Purity | Chiral HPLC | Separation of FMOC-DL-proline enantiomers on a chiral stationary phase; DL-ratio calculated from peak areas. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., DMF, DCM, methanol) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and Ni after acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after ignition at 700-800 C and weighing of residual residue. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 C using sodium D-line (589 nm); confirms chiral integrity and absence of racemization. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., FMOC-proline, dipeptide adducts, hydrolysis products) using gradient reversed-phase HPLC. |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Determination of hydrogen ion activity in aqueous suspension using calibrated glass electrode and pH meter. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size via light scattering pattern generated by dispersed particles in air stream. |
| Microbial Limits | Membrane Filtration and Plate Count | Enumeration of aerobic mesophilic microorganisms following filtration, membrane transfer to agar media, and colony counting after incubation. |
| Appearance | Visual Inspection | Assessment of physical state, color, and homogeneity against defined standards under controlled lighting and white background. |
Technical Specifications of FMoc-DL-proline
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15.0° to -19.0° (c=1, in DMF) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of FMoc-DL-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of FMoc-DL-proline
Industrial FMoc-DL-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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