Fmoc-L-Glutamic acid gamma-methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 145038-50-2 |
| Product name | Fmoc-L-Glutamic acid gamma-methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-L-Glutamic acid gamma-methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-L-Glutamic acid gamma-methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-L-Glutamic acid gamma-methyl ester
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Temporary protecting reagent for the glutamic acid side chain in solid-phase peptide synthesis (SPPS) | Used to selectively protect the γ-carboxyl group of L-glutamic acid during Fmoc-based SPPS, preventing side reactions during chain elongation; the Fmoc group enables cleavage under basic conditions, while the methyl ester is removed concurrently with resin cleavage during final acidic deprotection |
| Pharmaceutical R&D | Building block for therapeutic peptides and cyclic peptides containing glutamic acid residues | Serves as a key chiral building block in synthesizing glutamic acid–containing structures—such as GLP-1 analogs, antimicrobial peptides, and targeting peptides—where precise control over side-chain reactivity is required |
| Chemical Reagents | High-purity chiral amino acid derivative reference standard and custom synthesis starting material | Employed as an analytical reference standard or as a controlled starting material in GMP-compliant synthesis of peptide active pharmaceutical ingredients (APIs), following purification by recrystallization and chiral HPLC |
Manufacturing Quality Control of Fmoc-L-Glutamic acid gamma-methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 268 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; L-isomer content calculated from peak area ratio relative to reference. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., DMF, methanol, ethyl acetate) using flame ionization detection with headspace sampling. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to determine trace water based on stoichiometric reaction with iodine and sulfur dioxide. |
| Heavy Metals | ICP-OES | Multi-element detection after acid digestion; total heavy metals (Pb, Cd, Hg, As, Ni) quantified by atomic emission intensity. |
| Residual Chloride | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and conductivity detection. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., Fmoc-Glu-OH, Fmoc-Glu-OMe diastereomers) using gradient HPLC. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using sodium D-line light source in solution; confirms chiral integrity and concentration. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change; used for identity and purity screening. |
| Appearance | Visual Inspection | Assessment of physical state, color, and homogeneity against established reference standard under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying under vacuum at specified temperature; indicates volatile content including residual solvents and moisture. |
| pH of Solution | Potentiometric pH Measurement | pH determined in aqueous isopropanol solution using calibrated glass electrode; reflects acidic/basic impurity profile. |
Technical Specifications of Fmoc-L-Glutamic acid gamma-methyl ester
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -12.0 to -10.0 deg (c=1, DMF) |
| Melting Point | 138 to 142 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-L-Glutamic acid gamma-methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-L-Glutamic acid gamma-methyl ester
Safety Information of Fmoc-L-Glutamic acid gamma-methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-L-Glutamic acid gamma-methyl ester
Industrial Fmoc-L-Glutamic acid gamma-methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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