1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 14580-22-4 |
| Product name | 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
| Industry | Application | Process |
|---|---|---|
| Dye Industry | Intermediate for synthesizing azo dyes, used in producing acid, reactive, and metal-complex dyes | Used in diazotization-coupling reactions with aromatic amines to prepare azo dyes |
| Pharmaceutical Industry | Key synthetic intermediate for the antipyretic analgesic metamizole | Participates in the full synthesis route of metamizole via multi-step reactions including formylation, sulfonation, and condensation |
| Pesticide Industry | Structural building block for certain insecticides and plant growth regulators | Introduces the pyrazolone core into heterocyclic pesticide molecules to optimize biological activity |
Manufacturing Quality Control of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Characteristics | Visual Inspection, Physical Description | Observe the color, state (e.g., white or off-white crystalline powder), odor, solubility, etc., to ensure compliance with pharmacopoeia or internal control standards. |
| Melting Point | Capillary Melting Point Determination | Determine the melting range using a melting point apparatus and compare it with reference standards or literature values (typically around 120–125°C) to assess purity and crystal form consistency. |
| Content Determination (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 chromatographic column with methanol-water or acetonitrile-buffered salt as the mobile phase, and a UV detector (wavelength 254–280 nm) for detection. Calculate the main component content using external or internal standard methods, which offer high accuracy and specificity. |
| Related Substances (Impurity Profile) | HPLC Method (Gradient Elution) | Separate degradation products, synthetic intermediates, and isomers using gradient elution programs. Quantify impurities via peak area normalization or external standard method with reference substances, complying with ICH Q3B guidelines. |
| Moisture Content | Karl Fischer Titration | Determine trace moisture using an iodine-sulfur dioxide-pyridine-methanol system through coulometric or volumetric methods, ensuring dryness meets process requirements (usually ≤0.5%). |
| Solvent Residue | Gas Chromatography (GC) | Use headspace or direct injection with capillary columns to separate and detect residual organic solvents (e.g., methanol, ethanol, ethyl acetate, dichloromethane), controlled according to ICH Q3C standards. |
| Chlorine Content (or Chloride Ion) | Ion Chromatography (IC) or Oxygen Bomb Combustion + Ion-Selective Electrode | Determine chloride ion concentration using ion chromatography after oxygen bomb combustion of the sample, or directly using a chloride ion-selective electrode, ensuring that chlorine atoms in the structure are not lost or foreign chlorine impurities introduced. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Prepare a solution in ethanol or methanol and measure absorption peaks between 200–400 nm (typically λmax ≈ 270–290 nm) for qualitative identification and rapid concentration estimation (should be confirmed by HPLC). |
| Heavy Metal Content | Atomic Absorption Spectrometry (AAS) or ICP-MS | Determine heavy metal content such as lead, cadmium, mercury, and arsenic after sample digestion, complying with pharmacopoeia general chapters <232> or <233> limits (e.g., Pb ≤ 5 ppm). |
| Particle Size Distribution (if applicable) | Laser Diffraction or Microscopy | Measure particle size distribution for bulk drug powders to ensure uniformity and dissolution performance in subsequent formulation processes (if used in solid oral dosage forms). |
| Crystal Form Identification (if applicable) | X-ray Powder Diffraction (XRPD) | Compare characteristic diffraction patterns with reference crystal forms to confirm the presence of polymorphic forms, ensuring physical stability consistency across batches. |
| pH Value (in Aqueous Solution) | pH Meter Measurement | Determine the pH of the aqueous solution prepared from the sample to evaluate acidity or alkalinity, assessing whether acidic/alkaline impurities are present (pyrazolone derivatives typically show weak acidity, pH ≈ 5–7). |
Technical Specifications of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
| Test Item | Specification |
|---|---|
| Appearance | White to orange to green crystalline powder |
| Purity | >=98.0% (by LC-MS) |
| Melting Point | 148–152°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
Safety Information of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one
Industrial 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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