2-Chloroadenosine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 146-77-0 |
| Product name | 2-Chloroadenosine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Chloroadenosine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Chloroadenosine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Chloroadenosine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Antiviral drug intermediate | Used as a precursor compound in the synthesis of nucleoside antiviral drugs such as adefovir and tenofovir; active metabolites are obtained via phosphorylation and structural modification |
| Biochemical research | Reagent for RNA synthesis and modification | Applied as a chlorinated derivative of adenine base to introduce specific base modifications during solid-phase oligonucleotide synthesis, enabling investigation of nucleic acid structure–function relationships |
| Molecular diagnostics | Probe labeling and signal amplification component | Employed as a modified nucleoside in fluorescent or enzyme-labeled probe design to enhance hybridization specificity and detection sensitivity; commonly used in primer extension steps of real-time fluorescent PCR |
Manufacturing Quality Control of 2-Chloroadenosine
| Test Item | Common Test Method | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analysis of chemical shifts of hydrogen and carbon in the molecule using ¹H-NMR and ¹³C-NMR to confirm structural characteristics of the target compound. |
| Molecular Weight and Purity Confirmation | Mass Spectrometry (MS) | High-resolution mass spectrometry (e.g., ESI-MS or MALDI-TOF) is used to determine the molecular ion peak, verifying molecular weight and identifying impurity fragments. |
| Assay (Content Determination) | High-Performance Liquid Chromatography (HPLC-UV) | Using a reversed-phase column and UV detector (e.g., at 254 nm), the content of the main component is determined by external standard or area normalization method. |
| Related Substances / Impurity Analysis | HPLC-UV or UPLC-PDA | Optimized gradient elution conditions are used to separate and quantify potential process impurities and degradation products, meeting pharmacopoeial system suitability requirements. |
| Chiral Purity (if applicable) | Chiral High-Performance Liquid Chromatography (Chiral-HPLC) | Using a chiral stationary phase column to separate enantiomers and assess optical purity (applicable to derivatives containing chiral centers). |
| Water Content | Karl Fischer Titration | Volumetric or coulometric method is used to determine the water content in the sample, ensuring compliance with standards for loss on drying or moisture content. |
| Residual Solvents | Gas Chromatography (GC-FID or GC-MS) | Headspace or direct injection is used to detect organic solvents potentially remaining from the synthesis process, according to ICH Q3C guidelines. |
| Loss on Drying | Oven Drying Method | The sample is dried to constant weight at a specified temperature (e.g., 105°C), and the percentage weight loss is calculated to evaluate the content of volatile substances. |
| Melting Point | Capillary Melting Point Apparatus | The temperature range from initial melting to complete melting is measured, serving as a physical constant for identification and preliminary purity assessment. |
| pH Value (in solution) | pH Meter Measurement | The sample is prepared as an aqueous solution of defined concentration, and its pH value is measured to assess acid-base stability or formulation compatibility. |
Technical Specifications of 2-Chloroadenosine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -53.0 to -46.0 ° (c=1, in water) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Chloroadenosine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Chloroadenosine
Packaging of 2-Chloroadenosine
Industrial 2-Chloroadenosine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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