cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 146231-54-1 |
| Product name | cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 146231-54-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 146231-54-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 146231-54-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key Chiral Intermediate | Used in the synthesis of bictegravir and its salts (e.g., bictegravir sodium) to construct the core structure of the drug molecule. |
| Pharmaceutical Industry | Protease Inhibitor Synthesis | Serves as a chiral building block containing a pyrrolidinone moiety for the development and synthesis of HIV integrase inhibitors or other protease inhibitors. |
| Chemical Industry | Asymmetric Synthesis Reagent | Leverages its chiral center and highly reactive lactam ring to enable selective nucleophilic addition or ring-opening reactions, yielding downstream derivatives with high optical purity. |
Manufacturing Quality Control of 146231-54-1
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at characteristic wavelength, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of structurally related impurities using gradient HPLC with UV detection and relative response factors. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on retention time and peak area. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification by inductively coupled plasma mass spectrometry after acid digestion and dilution. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride anions using suppressed conductivity detection with standard calibration. |
| Residual Palladium | ICP-OES | Quantitative analysis of palladium residue after microwave-assisted digestion, measured by inductively coupled plasma optical emission spectroscopy. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using sodium D-line light source in a polarimeter to confirm chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing solid-to-liquid phase change under controlled heating rate. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution in suspension using Mie scattering theory and laser diffraction principles. |
| Residual TFA | GC-FID | Targeted quantification of trifluoroacetic acid using headspace GC-FID with derivatization if required. |
| Microbial Limits | Membrane Filtration and Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens using standardized culture media and incubation conditions. |
Technical Specifications of 146231-54-1
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.5% (GC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | [α]D²⁰ = -15.0 to -19.0° (c=1.0, CHCl₃) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 146231-54-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 146231-54-1
Packaging of 146231-54-1
Industrial 146231-54-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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