5-Methyluridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1463-10-1 |
| Product name | 5-Methyluridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Methyluridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Methyluridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Methyluridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key intermediate for antiviral agents (e.g., Stavudine) and anticancer drugs | Functional group transformation on the base or sugar moiety via chemical modification or biotransformation to synthesize target drug molecules |
| Pharmaceutical Industry | Starting material for nucleoside derivative synthesis | Preparation of nucleoside derivatives with specific pharmacological activity through glycosidic bond modification, base substitution, or introduction and removal of protecting groups |
| Biochemistry/Research | Reagent for biochemical and molecular biology research | Used as substrate or inhibitor in enzyme kinetics studies, or in nucleic acid structure synthesis and analysis |
| Chemical Synthesis | Protected nucleoside building blocks | Employed in organic synthesis to construct complex oligonucleotides via protecting group strategies, leveraging specific reactive sites |
Manufacturing Quality Control of 5-Methyluridine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| 5-Methyluridine Content | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 chromatographic column, with water-methanol or water-acetonitrile as the mobile phase for gradient elution. The UV detector (260–270 nm) is used to measure the peak area of 5-methyluridine. Quantification is performed using external standard or internal standard methods, suitable for purity and content determination. |
| 5-Methyluridine Purity | Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) | Utilizing the high separation efficiency of UHPLC combined with the high sensitivity and selectivity of mass spectrometry. Detection is carried out in multiple reaction monitoring (MRM) mode by monitoring characteristic ion pairs of 5-methyluridine (e.g., m/z 243.1 → 126.1). This method can exclude interference from structurally similar compounds and is suitable for precise quantification of trace impurities and main components. |
| Structural Confirmation of 5-Methyluridine | Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Analyzing characteristic chemical shifts in hydrogen and carbon spectra (e.g., the methyl proton at C5 around δ 2.25 ppm, and the C6-H around δ 7.75 ppm), combined with two-dimensional spectra (such as HSQC, HMBC) to confirm molecular structure. It is considered the gold standard method for structural confirmation of APIs. |
| Related Substances of 5-Methyluridine | HPLC-UV or UHPLC-MS | A gradient elution method is established to separate possible degradation products (such as uridine, cytidine, 5-methylcytidine, etc.). Impurity content is calculated by comparing retention time and peak area with reference substances, complying with ICH Q3B guidelines. |
| Moisture Content of 5-Methyluridine | Karl Fischer Titration | Using volumetric or coulometric methods to determine trace moisture content in the sample. Suitable for moisture control in APIs to ensure stability and solubility compliance with pharmacopoeia requirements (e.g., Chinese Pharmacopoeia General Chapter 0832). |
| Residual Solvents in 5-Methyluridine | Gas Chromatography (GC-FID / GC-MS) | Using headspace or direct injection, with capillary columns to separate and detect residual solvents such as ethanol, acetone, dichloromethane, etc. Limitation control is conducted according to ICH Q3C standards. |
| Polymorphic Analysis of 5-Methyluridine | Fourier Transform Infrared Spectroscopy (FT-IR) or X-ray Powder Diffraction (XRPD) | Determine the presence of polymorphs by analyzing characteristic absorption peaks (FT-IR) or diffraction peak positions and intensities (XRPD), ensuring consistency in formulation stability and bioavailability. |
Technical Specifications of 5-Methyluridine
| Test Item | Specification |
|---|---|
| Appearance | White Solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Optical Rotation | -10.0 to -7.0° (c=1, H2O) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Methyluridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Methyluridine
Packaging of 5-Methyluridine
Industrial 5-Methyluridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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