Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 146307-51-9 |
| Product name | Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 146307-51-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 146307-51-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 146307-51-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for antiviral drugs (e.g., synthesis of HIV protease inhibitors) | Drug synthesis |
| Pharmaceuticals | Key intermediate in the synthesis of statins such as atorvastatin | Asymmetric synthesis / chiral construction |
| Chemical Reagents | Building block for organic synthesis | Laboratory R&D |
| Fine Chemicals | Construction of complex molecules | Multi-step synthesis / functional group transformation |
Manufacturing Quality Control of 146307-51-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-220 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification via retention time matching and threshold-based reporting per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, THF, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine-methanol solvent system. |
| Heavy Metals | ICP-MS | Quantitative determination of elemental impurities (e.g., Pb, Cd, Ni, As) after acid digestion, using inductively coupled plasma mass spectrometry for sub-pptr detection. |
| Chiral Purity | Chiral HPLC-UV | Enantioselective separation on a chiral stationary phase followed by UV quantification to determine enantiomeric excess (ee) relative to the trans-4-(tert-butoxycarbonylamino)cyclohexane carboxylic acid methyl ester reference. |
| Acid Value | Acid-Base Titration | Neutralization of free carboxylic acid groups with standardized NaOH solution using phenolphthalein indicator or potentiometric endpoint detection. |
| Residual Boc Protecting Group Integrity | 1H NMR Spectroscopy | Qualitative and semi-quantitative assessment of tert-butoxycarbonyl group presence and absence of decomposition products (e.g., tert-butyl cation, isobutylene) via characteristic proton chemical shifts. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using controlled heating rate; confirms identity and crystallinity by comparison to literature or reference value. |
| Specific Optical Rotation | [alpha]D Measurement | Determination of optical activity using a polarimeter at 589 nm (Na D-line) to verify stereochemical integrity and batch-to-batch consistency. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or dispersed powder sample to determine volume-weighted particle size distribution (D10, D50, D90) per ISO 13320. |
| Microbiological Contamination | Membrane Filtration | Quantitative enumeration of aerobic microorganisms and absence testing for specified pathogens per USP <61> and <62>. |
Technical Specifications of 146307-51-9
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Melting Point | 75–79°C |
| Optical Rotation | -15.0 to -19.0° (c=1, in CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 146307-51-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 146307-51-9
Packaging of 146307-51-9
Industrial 146307-51-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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