N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 146727-62-0 |
| Product name | N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a protected amino acid building block in peptide synthesis to construct bioactive peptides containing D-configured and p-cyanophenylalanine residues | Solid-phase or liquid-phase peptide synthesis (SPPS/LPPS); Boc protecting group removed under acidic conditions |
| Medicinal Chemistry | Employed in the design and synthesis of targeted protease inhibitors or receptor ligands; the cyano group enhances molecular lipophilicity and metabolic stability | Structure-based drug design (SBDD); incorporated in fragment coupling or click chemistry modifications |
| Biochemical Research | Applied as a non-canonical amino acid probe to investigate protein conformation, enzyme active sites, or molecular recognition mechanisms | Site-specific incorporation techniques (e.g., cell-free expression systems or chemical semi-synthesis) coupled with spectroscopic or crystallographic analysis |
| Chemical Synthesis Intermediate | Utilized in the preparation of functional molecules or fluorescent labeling precursors featuring aryl cyanide motifs | The cyano group is further converted to amides, carboxylic acids, or tetrazoles, enabling subsequent coupling reactions |
Manufacturing Quality Control of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation of D- and L-enantiomers on a chiral stationary phase, with UV detection and calculation of enantiomeric excess from peak area ratios. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common organic solvents (e.g., DMF, ethyl acetate, methanol) based on calibrated retention times and response factors. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration using iodine generated in situ to quantitatively determine water content via stoichiometric reaction with iodine and sulfur dioxide in pyridine/methanol medium. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification of trace heavy metals after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppt detection sensitivity. |
| Residual Palladium | ICP-OES | Quantitative analysis of palladium residue (e.g., from coupling catalysts) after microwave-assisted acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Appearance (Color & Clarity) | Visual Inspection (against USP <901>) | Comparison of dissolved sample solution (in specified solvent, e.g., acetonitrile/water) to standard color solutions and assessment of particulate clarity under controlled lighting. |
| Specific Optical Rotation | [α]D | Measurement of plane-polarized light rotation in a sodium D-line (589 nm) cell at specified concentration, temperature, and path length to confirm chiral identity and batch consistency. |
| Related Substances (Impurities) | HPLC-UV (Gradient) | Identification and quantification of structurally related impurities (e.g., Boc-D-phenylalanine, deprotected amine, hydrolysis/by-product peaks) using gradient elution and UV detection. |
| Loss on Drying (LOD) | Thermogravimetric Analysis (TGA) or Vacuum Oven Method | Determination of volatile matter by measuring mass loss upon controlled heating under vacuum or nitrogen, per USP <731>. |
Technical Specifications of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | +15.0 to +19.0° (c=1, in 1M HCl) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
Safety Information of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine
Industrial N-tert-Butoxycarbonyl-4-cyanophenyl-D-alanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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