China Factory Direct
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| CAS number | 147-85-3 |
| Product name | L-Proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeFood GradeCosmetic Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Food Industry | Food Additive | Used in the production of various food additives, such as flavor enhancers |
| Pharmaceutical Industry | Raw Material for Drug Synthesis | Serves as an intermediate or raw material in the synthesis of certain pharmaceuticals |
| Cosmetics Industry | Skincare Ingredient | Applied as a moisturizing and anti-aging ingredient in skincare formulations |
| Nutritional Supplements | Dietary Supplementation | Used as an amino acid supplement for nutritional fortification |
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with a UV detector (typically at 195–210 nm wavelength); qualitative identification is based on retention time, and quantitative analysis is performed by peak area to accurately determine the purity and content of L-proline. |
| Amino Acid Automatic Analyzer | Employs ion-exchange chromatography combined with post-column derivatization to automatically separate and detect amino acid components; suitable for simultaneous analysis of multiple amino acids with high selectivity and sensitivity for L-proline. | |
| Identification Test | Infrared Spectroscopy (IR) | Compares the infrared absorption spectrum of the sample with that of a reference standard; confirms structural consistency based on characteristic absorption peaks of functional groups such as carboxyl and secondary amine groups. |
| Specific Optical Rotation | Measures the specific optical rotation of an aqueous solution of L-proline using sodium D-line light (589 nm); compares the result with the standard range (+30.0° to +33.0°) to verify its optical activity. | |
| Water Content | Karl Fischer Titration | Based on the quantitative reaction of iodine and sulfur dioxide with water in an anhydrous environment; measures water content precisely via coulometric titration, suitable for detecting trace amounts of moisture. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Method | Determines the mass of inorganic residues remaining after high-temperature incineration of the sample, reflecting the level of inorganic impurities and meeting pharmacopeial requirements for amino acid purity. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detects residual levels of toxic metallic elements such as lead, arsenic, cadmium, and mercury to ensure compliance with safety standards for pharmaceutical or food-grade products. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separates L-proline from possible impurities (e.g., other amino acids or degradation products) using gradient or isocratic elution to evaluate purity and assess impurity limits. |
| pH Value | pH Meter Method | Prepares an aqueous solution of L-proline at a specified concentration (e.g., 1% w/v) and measures its acidity or alkalinity using a calibrated pH meter to verify compliance with the specified range (typically 5.9–6.9). |
| Microbial Limits | Microbial Culture Method | Performs testing in accordance with pharmacopeial requirements for total aerobic microbial count, mold and yeast counts, and specified control organisms (e.g., Escherichia coli, Salmonella spp.) to ensure microbiological safety of the product. |
| Test Item | Specification |
|---|---|
| Appearance | White crystals or powder |
| Assay | 98.5 ~ 101.5% |
| Specific rotation D25 | -84.3° ~ -86.3° |
| Loss on drying | ≤0.4% |
| Ignition residue | ≤0.4% |
| Chloride | ≤0.05% |
| Sulfate | ≤0.03% |
| Iron | ≤30 ppm |
| Pb | ≤15 ppm |
| Single impurity | ≤0.5% |
| Total impurity | ≤2.0% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.