4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 147118-36-3 |
| Product name | 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 147118-36-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 147118-36-3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 147118-36-3
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for tyrosine kinase inhibitors | Used in the synthesis of targeted therapeutics, such as anticancer agents |
| Pharmaceuticals | Development of drugs for chronic myeloid leukemia | Preparation of imatinib analogues or derivatives |
| Pharmaceuticals | Research and development of other antitumor agents | Introduction of specific functional groups to optimize pharmacological activity |
| Chemical Manufacturing | Key building block in organic synthesis | Construction of complex heterocyclic compound structures |
| Research | Applications in biochemistry and medicinal chemistry research | Molecular structure modification to explore new biological activities |
Manufacturing Quality Control of 147118-36-3
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification (Identity) | Fourier Transform Infrared Spectroscopy (FT-IR) Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR) Mass Spectrometry (MS) |
Confirm molecular structure through characteristic functional group absorption peaks in IR, chemical shifts and coupling constants of hydrogen atoms in NMR, and molecular ion peaks along with fragment ions in MS. |
| Assay (Content Determination) | High-Performance Liquid Chromatography (HPLC) | Utilize a reversed-phase C18 column with phosphate buffer/acetonitrile or methanol as mobile phase, and UV detection (typically at 220–260 nm) for quantitative determination of the main component. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Same chromatographic conditions as assay or gradient elution program to separate and quantify process impurities, degradation products (e.g., desmethylsulfonyl derivatives, oxidation products, dimers, etc.). |
| Residual Solvents | Gas Chromatography (GC), Headspace Sampling | Determine residual levels of organic solvents (e.g., methanol, ethanol, dichloromethane, toluene, DMF) used during synthesis according to ICH Q3C guidelines. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Drying Method | Measure the percentage loss of volatile components (mainly water and low-boiling solvents) by drying at a specified temperature (e.g., 105°C) until constant weight. |
| Residue on Ignition | High-Temperature Incineration Method | After high-temperature ignition (typically 700–800°C), weigh the inorganic residue to assess total inorganic impurity content. |
| Water Content | Karl Fischer Titration | Specifically determines water content in samples; essential for quality control of moisture-sensitive active pharmaceutical ingredients. |
| Optical Rotation (if applicable) | Polarimeter | If the compound has chiral centers and exists as a single enantiomer, measure specific optical rotation to confirm optical purity. |
| Particle Size Distribution (for formulations) | Laser Particle Size Analyzer | Control particle size to influence downstream formulation processes (e.g., flowability, dissolution rate). |
| Polymorphism | X-Ray Powder Diffraction (XRPD) Differential Scanning Calorimetry (DSC) |
Determine the presence of polymorphic forms; different polymorphs may affect stability and bioavailability. |
Technical Specifications of 147118-36-3
| Test Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 147118-36-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 147118-36-3
Packaging of 147118-36-3
Industrial 147118-36-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply