4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 147118-37-4 |
| Product name | 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 147118-37-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 147118-37-4 Supplier from China
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Industrial Applications of 147118-37-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of sitagliptin | Used in multi-step organic synthesis, including condensation, reduction, and coupling reactions, to construct the core structure of dipeptidyl peptidase-4 (DPP-4) inhibitors |
Manufacturing Quality Control of 147118-37-4
| Test Item | Commonly Used Testing Methods | Method Overview |
|---|---|---|
| Structure Confirmation | Nuclear Magnetic Resonance (NMR) | Confirm the chemical shifts and connectivity of hydrogen and carbon atoms in the molecule using ¹H NMR, ¹³C NMR, and 2D spectra (e.g., HSQC, HMBC) to verify structural accuracy. |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column and UV detector (e.g., 254 nm), with gradient elution to determine the percentage area of the main peak, assessing sample purity (typically required ≥98.0%). |
| Impurity Detection | HPLC-UV / HPLC-MS | Separate impurity peaks using HPLC and identify known or unknown impurities with mass spectrometry (MS); set impurity limits (e.g., individual impurity ≤0.1%, total impurities ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents (e.g., methanol, ethyl acetate, DMF) from synthesis using headspace or direct injection GC-FID/MS, based on ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Use volumetric or coulometric KF titrator to accurately measure water content in the sample (typically required ≤0.5%) to ensure product stability. |
| Loss on Drying | Drying Method (105°C to constant weight) | Dry the sample at a specified temperature until constant weight is achieved, then calculate the percentage weight loss to assess the content of volatile substances (including water and low-boiling solvents). |
| Melting Point Determination | Capillary Melting Point Apparatus | Determine the melting temperature range of the compound as a physical constant to assist in assessing purity and crystal form consistency (should be compared with literature values). |
| Heavy Metal Residues | ICP-MS or Atomic Absorption Spectroscopy (AAS) | According to the Chinese Pharmacopoeia or ICH Q3D guidelines, detect elemental impurities such as Pb, As, Cd, and Hg to ensure compliance with safety limits (e.g., ≤10–20 ppm). |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRPD) | Identify crystal form by characteristic diffraction peak positions and intensities to ensure batch-to-batch consistency and prevent differences in solubility or bioavailability due to crystal form variation. |
| Content Determination | External Standard Method by HPLC | Using a reference standard of known purity, establish a standard curve and calculate the content of the target compound in the sample via peak area (typically required 98.0–102.0%). |
| Chiral Purity (if applicable) | Chiral HPLC | If the molecule contains a chiral center, use a chiral column to separate enantiomers and ensure optical purity (e.g., ee ≥99%). |
| Stability-Related Substances | Accelerated/Long-Term Stability Testing + HPLC | Place samples under different temperature and humidity conditions, periodically sample and analyze using HPLC to monitor degradation products and assess storage conditions and shelf life. |
Technical Specifications of 147118-37-4
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 147118-37-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 147118-37-4
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Industrial 147118-37-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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