(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 147266-92-0 |
| Product name | (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 147266-92-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 147266-92-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 147266-92-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for synthesizing peptide-based drugs or protease inhibitors | Introduced via BOC protection in solid-phase or solution-phase peptide synthesis |
| Biochemistry | Protein structure modification or enzyme activity studies | Coupling reaction with target protein in buffered solution |
| Materials Science | Functional monomer for modifying high-performance polymers | Incorporated into polymer chains via free-radical polymerization or condensation polymerization |
| Drug Discovery | Building block for synthesizing drug-like compound libraries | High-throughput screening using combinatorial chemistry methods |
| Diagnostics Reagents | Spacer arm for immunoassay labeling agents | Coupled to antibody/antigen amino groups via activated carboxyl group |
Manufacturing Quality Control of 147266-92-0
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~200–210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment via separation on a chiral stationary phase (e.g., Chiralpak AD-H), with UV detection and comparison to enantiopure reference. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., THF, DMF, EtOAc) using gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine/methanol buffer system. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Ni, Fe) after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residues post-hydrogenation using inductively coupled plasma optical emission spectroscopy following microwave-assisted acid digestion. |
| Related Substances | HPLC-UV (Forced Degradation) | Detection and quantification of structurally related impurities (e.g., de-BOC derivative, epimer, oxidation products) under stressed conditions (acid/base/oxidative/thermal). |
| Loss on Drying (LOD) | Gravimetric Analysis | Mass loss measured after drying under controlled temperature/vacuum; reflects volatile content including residual solvents and moisture. |
| Optical Rotation | [α]D Measurement | Specific rotation determined using a polarimeter at 589 nm (Na-D line), confirming identity and chiral integrity relative to pharmacopeial reference. |
| Particle Size Distribution | Laser Diffraction | Dry or wet dispersion analysis measuring size distribution by angular scattering intensity of laser light, relevant for filtration and formulation handling. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | pH measured in a defined aqueous suspension (e.g., 1% w/v) using a calibrated pH electrode, indicating potential acidic/basic degradation or salt formation. |
| Microbial Limits | Membrane Filtration & Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens (e.g., E. coli, S. aureus) per ICH Q5A and USP <61>/<62>. |
Technical Specifications of 147266-92-0
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 168-172°C |
| Optical Rotation | +65 to +75° (c=1, in 1M HCl) |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 147266-92-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 147266-92-0
Packaging of 147266-92-0
Industrial 147266-92-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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