(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 147489-06-3 |
| Product name | (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 147489-06-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 147489-06-3 Supplier from China
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Industrial Applications of 147489-06-3
| Industry | Application | Process Description |
|---|---|---|
| Pharmaceutical R&D | HMG-CoA reductase inhibitors | Used as a structural analog of statin drugs to suppress cholesterol biosynthesis, with potential lipid-regulating activity |
| Pharmaceutical Synthesis | Intermediate | Applied in the synthesis of quinoline-containing statin derivatives for the development and preparation of anti-hyperlipidemic agents |
| Biochemical Research | Enzyme inhibition studies | Used to investigate inhibitory activity against HMG-CoA reductase and assess its regulatory role in the cholesterol metabolism pathway |
| Pharmaceutical Analysis | Reference standard | Employed as a reference material in pharmaceutical analysis and quality control to support detection and identification of related statin compounds |
Manufacturing Quality Control of 147489-06-3
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm based on peak area response against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification via retention time comparison and threshold-based reporting. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., toluene, ethyl acetate) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration using iodine generation and stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) after acid digestion using inductively coupled plasma mass spectrometry. |
| Optical Purity (Enantiomeric Excess) | Chiral HPLC-UV | Resolves enantiomers on a chiral stationary phase and calculates ee% from peak area ratio of (4R,6S) vs. (4S,6R) isomer. |
| Diastereomeric Purity | HPLC-UV | Evaluates diastereomeric impurities using optimized reversed-phase or normal-phase HPLC with UV detection. |
| Residual Palladium | ICP-OES | Measures palladium content post-catalyst removal by inductively coupled plasma optical emission spectroscopy after microwave digestion. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid groups by titration with standardized NaOH solution using phenolphthalein indicator. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C followed by weighing of residual residue. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution using light scattering principles and Mie theory. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms and specified pathogens (e.g., E. coli, S. aureus) by filtration, culture, and colony enumeration. |
Technical Specifications of 147489-06-3
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +13.0 to +14.0° (c=1, in CHCl₃) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 147489-06-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 147489-06-3
Packaging of 147489-06-3
Industrial 147489-06-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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