Indole-2-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1477-50-5 |
| Product name | Indole-2-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Indole-2-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Indole-2-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Indole-2-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) | Used as an intermediate in condensation reactions |
| Pesticides | Preparation of plant growth regulators | Applied in esterification or amidation reactions |
| Dyes | Production of acid dyes | Employed in substitution reactions to introduce specific functional groups |
| Materials Science | Preparation of optoelectronic functional materials | Participates in polymerization reactions to form conjugated structures |
Manufacturing Quality Control of Indole-2-carboxylic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe sample color, crystal form, and state (typically white to off-white crystalline powder), and measure melting point (literature value approximately 260–265°C) to determine compliance with pharmacopoeial or enterprise standards. |
| Identification | Infrared Spectroscopy (IR) | Compare infrared absorption spectrum with reference spectrum to identify characteristic functional groups (e.g., carboxyl C=O stretching vibration around 1680 cm⁻¹, C=C/C=N vibrations of indole ring). |
| High-Performance Liquid Chromatography (HPLC) | Compare retention time with reference standard. Under identical chromatographic conditions (e.g., C18 column, methanol-water/buffer gradient elution), confirm consistency of main peak retention time. | |
| Ultraviolet-Visible Spectroscopy (UV-Vis) | Measure UV absorption spectrum in ethanol or methanol; characteristic absorption peaks typically appear at 220–230 nm and 280–300 nm (π→π* transitions of indole ring), used for qualitative confirmation. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Quantify using external or internal standard method with UV detection (common detection wavelengths: 254 nm or 280 nm). Calculate 2-Indoleacetic acid content via calibration curve; meet pharmacopoeial requirements (e.g., ≥98.0%). |
| Titration (Acid-Base Titration) | Exploit the acidity of the carboxyl group by titrating with standardized sodium hydroxide solution in aqueous or non-aqueous medium (using phenolphthalein or potentiometric endpoint detection); suitable for rough content estimation. | |
| Impurity Testing | High-Performance Liquid Chromatography (HPLC) | Analyze impurity profile using gradient elution to separate potential structurally related impurities (e.g., indole, 3-indoleacetic acid, indole ketone); control individual impurity ≤0.5% and total impurities ≤1.0%. |
| Thin-Layer Chromatography (TLC) | Suitable for rapid screening; use silica gel plates with developing solvent (e.g., ethyl acetate:methanol = 9:1), visualize under UV light or iodine vapor, and compare spot positions and numbers with reference standard. | |
| Water Content | Karl Fischer Titration | Accurately determine trace moisture content; control level ≤0.5% (depending on formulation or process requirements) to prevent hygroscopicity from affecting stability. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection to detect residual organic solvents from manufacturing (e.g., methanol, ethanol, ethyl acetate), ensuring compliance with ICH Q3C guidelines. |
| Heavy Metals and Elemental Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of heavy metals such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmacopoeial limits (e.g., Pb ≤5 ppm); particularly important for active pharmaceutical ingredients intended for export or high-purity applications. |
| Particle Size Distribution (if applicable) | Laser Diffraction / Microscopy | For powder-based formulations, measure particle size distribution to ensure solubility and process uniformity (not mandatory, depends on intended use). |
| Solubility | Shake Flask Method + HPLC Quantification | Determine equilibrium solubility in aqueous solutions of different pH values (e.g., pH 1.2, 6.8, 7.4) to evaluate correlation between physicochemical properties and bioavailability. |
Technical Specifications of Indole-2-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to orange crystalline powder |
| Purity | >=98.0% (HPLC) |
| Melting Point | 162–166°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Indole-2-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Indole-2-carboxylic acid
Packaging of Indole-2-carboxylic acid
Industrial Indole-2-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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