(3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 148214-90-8 |
| Product name | (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 148214-90-8
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 148214-90-8 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 148214-90-8
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for synthesizing protease inhibitors (e.g., HIV protease inhibitors) | Produced via asymmetric synthesis or chiral resolution; serves as a key building block in multi-step coupling reactions leading to active pharmaceutical ingredient (API) synthesis |
| Pharmaceuticals | Synthesis of NS3/4A protease inhibitors (e.g., drugs for hepatitis C treatment) | Used as a proline scaffold precursor; the core drug structure is constructed through acylation, reduction, cyclization, and related steps |
| Pharmaceuticals | Synthesis of antiviral and antitumor small-molecule drugs | Employed as a non-natural amino acid derivative in solid-phase or solution-phase peptide synthesis, participating in condensation reactions to form peptide analogues |
| Chemical R&D | Chiral building block for designing novel organic catalysts or ligands | Modified via functional group transformations (e.g., ester hydrolysis, amine protecting group removal) to construct chiral amine catalysts or metal ligands |
Manufacturing Quality Control of 148214-90-8
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a reference standard. |
| Chiral Purity | (R,R)-Enantiomeric Excess | Chiral HPLC with chiral stationary phase, measuring ratio of (3R,4R) to (3S,4S) and other diastereomers. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., THF, EtOAc, MeOH) using capillary GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generation to quantify water based on stoichiometric reaction with Karl Fischer reagent. |
| Heavy Metals | ICP-MS | Detects trace metal impurities (e.g., Pd, Ni, Fe) by plasma ionization and mass spectrometric quantification. |
| Residual Palladium | ICP-OES | Measures palladium catalyst residue via atomic emission from inductively coupled plasma after acid digestion. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid groups by titration with standardized NaOH using phenolphthalein or potentiometric endpoint. |
| Optical Rotation | Polarimetry | Measures specific rotation at 20 C using sodium D-line light to confirm chiral integrity and concentration. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size by measuring angular scattering pattern of laser beam passed through dispersed sample. |
| Related Substances | HPLC-UV (Forced Degradation) | Identifies and quantifies degradants and impurities using stability-indicating HPLC method with acidic/oxidative/thermal stress conditions. |
| Residual tert-Butyl Carbamate | GC-MS | Detects and quantifies residual Boc group cleavage byproducts (e.g., isobutylene, tert-butanol) via gas chromatography-mass spectrometry. |
| Microbial Contamination | Membrane Filtration | Quantifies aerobic microorganisms by filtering solution through membrane, then culturing on soybean-casein digest agar under controlled conditions. |
Technical Specifications of 148214-90-8
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C to 132°C |
| Optical Rotation | +24.0° to +26.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 148214-90-8
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 148214-90-8
Packaging of 148214-90-8
Industrial 148214-90-8 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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