N-Cbz-L-histidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 14997-58-1 |
| Product name | N-Cbz-L-histidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Cbz-L-histidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Cbz-L-histidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Cbz-L-histidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Used as an amino acid protecting group for synthesizing peptide-based drug intermediates | Applied in peptide synthesis to selectively protect the histidine α-amino group via carbobenzyloxy (Cbz) derivatization, enabling controlled coupling reactions |
| Biopharmaceuticals | Used to synthesize histidine-containing bioactive peptides and protein analogs | Leveraged for selective protection of both the side-chain and α-amino groups to achieve precise sequence assembly in solid-phase or solution-phase peptide synthesis |
| Chemical Research | Employed as a standard reagent for investigating histidine function in biological systems | Applied as a well-defined histidine precursor in enzyme kinetics, protein folding, and molecular recognition studies |
| Advanced Materials | Used to develop biocompatible functional polymers or nanomaterials | Applied in graft copolymerization or crosslinking reactions via reactivity of the amino group and imidazole ring to fabricate biomaterials |
Manufacturing Quality Control of N-Cbz-L-histidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 210 nm. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase with UV detection; L-isomer content calculated relative to total histidine derivative. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine, sulfur dioxide, and base in methanol/pyridine solvent; measures free and bound water. |
| Residual Solvents | GC-FID | Gas chromatographic separation followed by flame ionization detection; quantifies common solvents (e.g., ethyl acetate, methanol, DMF) per ICH Q3C. |
| Heavy Metals | ICP-OES | Multi-element detection via inductively coupled plasma optical emission spectroscopy after acid digestion; measures Pb, Cd, Hg, As, Ni. |
| Chloride Impurity | Ion Chromatography | Anion-exchange separation with suppressed conductivity detection; quantifies chloride ion from residual HCl or Cbz-Cl byproducts. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., N-Cbz-histidine diketopiperazine, de-Cbz product) using gradient RP-HPLC. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation at 589 nm using a polarimeter; confirms chiral integrity and batch-to-batch consistency. |
| pH of Solution | Potentiometric pH Measurement | Determination of aqueous solution pH (1% w/v) using calibrated glass electrode; reflects residual acidic/basic impurities. |
| Loss on Drying | Gravimetric Thermogravimetry | Weight loss measured after drying at 105 C for 2 hours; indicates volatile impurities and residual solvents. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms and absence testing for specified pathogens per USP <61> and <62>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory; ensures consistent handling and dissolution behavior. |
Technical Specifications of N-Cbz-L-histidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 235-240 °C (decomposes) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | +16.0 to +19.0 ° (c=1, 1M HCl) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Cbz-L-histidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Cbz-L-histidine
Packaging of N-Cbz-L-histidine
Industrial N-Cbz-L-histidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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