N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 152460-10-1 |
| Product name | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | JAK2 inhibitor intermediate | Used as a key intermediate in the synthesis of antitumor agents or therapeutics for myeloproliferative disorders, participating in multi-step organic synthesis reactions |
| Biological Research | Protein kinase inhibitor research | Applied in in vitro biological assays to evaluate selective inhibitory activity against JAK2 and other related kinases |
Manufacturing Quality Control of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification relies on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, acetone, toluene) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration where iodine reacts stoichiometrically with water in a pyridine-methanol solvent system. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni, Cu) after acid digestion using inductively coupled plasma mass spectrometry for multi-element detection. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after anion exchange separation. |
| Sulfate Impurity | Ion Chromatography | Separates and quantifies sulfate ions using suppressed conductivity detection after anion exchange separation. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing (700–800 C) and weighing of the ignited sample. |
| Particle Size Distribution | Laser Diffraction | Determines size distribution of solid particles in suspension by analyzing angular variation in laser light scattering intensity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid using calibrated capillary tube and controlled heating ramp. |
| Optical Rotation | Polarimetry | Quantifies specific rotation of chiral compounds using plane-polarized light passing through a solution in a temperature-controlled cell. |
| Microbial Limits | Membrane Filtration | Detects and enumerates aerobic microorganisms by filtering sample through membrane, culturing on agar media, and counting colony-forming units. |
Technical Specifications of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 192–196 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Safety Information of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
| Pictograms |    |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Industrial N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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