4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 152628-03-0 |
| Product name | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for angiotensin II receptor blockers (ARBs) | Used as a key intermediate in the synthesis of sartan-class antihypertensive drugs, participating in condensation, cyclization, and related reaction steps |
| Fine Chemicals | Organic synthesis building block | Applied in constructing benzimidazole-based functional molecules, with target structures introduced via esterification, amidation, or coupling reactions |
Manufacturing Quality Control of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with water-methanol or acetonitrile gradient elution. The main peak area is detected by UV detector (254–280 nm), and content is calculated using an external standard method. This method also allows assessment of impurity profile. |
| Impurity Profile Analysis | HPLC-UV / HPLC-MS | After HPLC separation, impurities such as degradation products, synthesis intermediates, and isomeric impurities (e.g., decarboxylated, oxidized products, or unreacted starting materials) are identified using mass spectrometry with ESI ion source. |
| Carboxyl Group Content (Quantitative) | Non-aqueous Titration | Titration of carboxyl groups using perchloric acid standard solution in glacial acetic acid medium, with crystal violet as indicator. Suitable for quantitative confirmation of acidic functional groups in active pharmaceutical ingredients (APIs). |
| Water Content | Karl Fischer Titration | Determines trace moisture in samples using coulometric or volumetric methods, ensuring adequate dryness of the material to prevent hydrolysis or changes in crystalline form that may affect stability. |
| Melting Point | Melting Point Apparatus | Determination of melting range (expected approximately 220–240°C) for preliminary identification and purity evaluation, compared against literature values. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection with capillary column separation to detect residual organic solvents from synthesis (e.g., DMF, ethanol, ethyl acetate), compliant with ICH Q3C guidelines. |
| UV Absorption Characteristics | UV-Visible Spectrophotometry (UV-Vis) | Determination of maximum absorption wavelength (λmax, typically between 260–290 nm) in methanol or acetonitrile, used for developing quantitative analytical methods and as an identification criterion. |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRPD) | Used to confirm consistency of the drug substance's crystalline form, avoiding differences in dissolution rate and stability due to polymorphism (particularly important during formulation development). |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detection of heavy metal elements such as lead, cadmium, mercury, and arsenic, in compliance with pharmacopeial limits (e.g., USP <232> or EP 2.5.10). |
| pH Value (Aqueous Solution) | pH Meter Measurement | pH is measured in saturated aqueous solution or diluted solution to evaluate acidic characteristics (due to presence of carboxyl group, pH is typically between 3–5). |
| Solubility | Shake Flask Method / HPLC Quantification | Equilibrium solubility is determined in various pH buffers (e.g., pH 1.2, 4.5, 6.8) and water to support formulation development and bioavailability prediction. |
Technical Specifications of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 248–252 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Safety Information of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Industrial 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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