4-Bromoisoquinoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1532-97-4 |
| Product name | 4-Bromoisoquinoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeElectronic GradeMaterial GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Bromoisoquinoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Bromoisoquinoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Bromoisoquinoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Small-molecule drug intermediates for synthesizing antitumor, antiviral, and kinase inhibitor compounds | Constructing the isoquinoline core structure via cross-coupling reactions such as Suzuki coupling and Buchwald-Hartwig amination |
| Agrochemical R&D | Structural modification unit for novel insecticides and fungicides | Introduced as a heterocyclic building block into active molecules to enhance target-binding affinity and metabolic stability |
| Organic Optoelectronic Materials | Functionalized doping material precursor for OLED emissive and electron-transport layers | Preparation of brominated isoquinoline ligands coordinated to iridium or platinum complexes via metal-catalyzed cyclization or coordination polymerization |
| Chemical Reagents | High-selectivity halogen labeling reagent for isotopic labeling and fluorescent probe synthesis | Functional group introduction via bromine-lithium exchange followed by addition to aldehydes/ketones, or palladium-catalyzed coupling with boronic acid derivatives |
Manufacturing Quality Control of 4-Bromoisoquinoline
| Test Item | Common Testing Method | Method Description |
|---|---|---|
| Purity Determination | High-Performance Liquid Chromatography (HPLC) | Utilizes a reverse-phase chromatographic column with methanol/water or acetonitrile/water as mobile phase. UV detector (e.g., 254 nm) quantifies the main component peak area to calculate purity. Suitable for accurately determining the ratio of organic impurities to the main component. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyzes hydrogen and carbon atom chemical shifts and coupling splitting patterns through ¹H NMR and ¹³C NMR spectra to confirm molecular structure and substitution positions, ensuring they match the characteristics of 4-bromoisoquinoline. |
| Impurity Analysis | Gas Chromatography-Mass Spectrometry (GC-MS) | Suitable for analyzing volatile or semi-volatile impurities. Identifies unknown impurities via mass spectral library comparison, combining retention time for qualitative and quantitative analysis. Particularly suitable for detecting solvent residues or byproducts. |
| Content Determination | Liquid Chromatography-Mass Spectrometry (LC-MS) | Uses a highly selective mass spectrometric detector (e.g., ESI+ mode) for accurate quantification of target compounds. Strong resistance to interference, especially suitable for quantifying trace components in complex matrices. |
| Loss on Drying | Oven Drying Method | The sample is placed in a 105°C constant temperature oven until it reaches a constant weight. The percentage of mass loss is calculated to evaluate moisture and volatile content, meeting pharmacopoeia standard requirements. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) | Uses headspace sampling technique to avoid matrix interference, combined with FID or MS detectors to quantitatively detect residual organic solvents (e.g., dichloromethane, ethanol) from the synthesis process. |
| Melting Point Determination | Capillary Melting Point Apparatus Method | Bases on the inherent physical property of the substance to determine the temperature range from initial melting to complete melting, assessing product crystalline purity and whether polymorphism or impurities are present. |
| Appearance and Color | Visual Color Comparison Method | Observes solid color (should be white to off-white crystals) under standard daylight, comparing it with a reference color solution to assess discoloration caused by oxidation or impurities. |
| Heavy Metal Residues | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | High-sensitivity simultaneous detection of multiple elements, capable of measuring trace heavy metals (e.g., Pb, As, Cd, Hg) at the ppb level, ensuring compliance with ICH Q3D or pharmacopoeia limit requirements. |
Technical Specifications of 4-Bromoisoquinoline
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 112-116°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Bromoisoquinoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Bromoisoquinoline
Packaging of 4-Bromoisoquinoline
Industrial 4-Bromoisoquinoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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