N-BOC-4-CHLORO-PIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 154874-94-9 |
| Product name | N-BOC-4-CHLORO-PIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-BOC-4-CHLORO-PIPERIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-BOC-4-CHLORO-PIPERIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-BOC-4-CHLORO-PIPERIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for synthesizing targeted antitumor agents (e.g., BTK inhibitors) and neuromodulators | Substitution reaction with amines under inert atmosphere, followed by BOC deprotection |
| Pharmaceutical R&D | Structural building block for constructing piperidine-containing proteolysis-targeting chimeras (PROTACs) | Introduction of aryl/heteroaryl groups via Suzuki coupling or SNAr reaction, followed by acid-mediated deprotection |
| Agrochemical R&D | Synthetic precursor for chlorinated piperidine structural units in novel insecticidal molecules | Nucleophilic substitution with thiols or amines to form C–S or C–N bonds |
| Materials Science | Structural module for functionalized organic ligands in metal–organic framework (MOF) design | Selective modification of the piperidine nitrogen atom prior to coordination with metal salts (e.g., Zn²⁺, Cu²⁺) |
Manufacturing Quality Control of N-BOC-4-CHLORO-PIPERIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and identification of impurities (e.g., de-Boc, hydrolyzed, or isomeric by-products) via retention time matching and spectral confirmation. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., THF, DCM, MeOH) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, achieving sub-pptr detection limits. |
| Chloride Ion Impurity | Ion Chromatography (IC) with Conductivity Detection | Separation of anions on anion-exchange column and quantitative detection of Cl⁻ based on electrical conductivity response. |
| Optical Rotation | [α]D Measurement | Determination of specific optical rotation using a polarimeter at 589 nm to confirm chiral integrity and enantiomeric purity. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue after controlled high-temperature ashing to assess inorganic ash content per USP <281>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using Mie scattering theory to determine D10/D50/D90 values. |
| Melting Point | Capillary Melting Point Apparatus | Thermal determination of solid–liquid phase transition range using calibrated digital melting point instrument per USP <741>. |
Technical Specifications of N-BOC-4-CHLORO-PIPERIDINE
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Conforms to reference standard |
| Optical Rotation | -15° to -25° (c=1, in MeOH) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-BOC-4-CHLORO-PIPERIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-BOC-4-CHLORO-PIPERIDINE
Packaging of N-BOC-4-CHLORO-PIPERIDINE
Industrial N-BOC-4-CHLORO-PIPERIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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