(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 155899-66-4 |
| Product name | (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 155899-66-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 155899-66-4 Supplier from China
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Industrial Applications of 155899-66-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for the antiviral drug remdesivir, used to construct the core cyclic structure of nucleoside analogues | In the total synthesis of remdesivir, this compound serves as a C4-hydroxy/C6-amino bifunctional chiral building block in nucleoside side-chain construction, undergoing phosphorylation, glycosylation, and coupling steps |
Manufacturing Quality Control of 155899-66-4
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Confirm atomic connectivity and stereochemistry within the molecule using ¹H-NMR, ¹³C-NMR, and 2D spectra (e.g., HSQC, HMBC). |
| Molecular Weight and Elemental Composition | High-Resolution Mass Spectrometry (HRMS) | Precisely measure the molecular ion peak to verify molecular formula, isotope distribution, and confirm the compound's molecular weight. |
| Chiral Purity / Stereochemistry | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral columns to separate enantiomers and assess the purity of the target stereoisomer (e.g., ee value). |
| Assay (Content Determination) | High-Performance Liquid Chromatography (HPLC-UV/ELSD) | Quantify the main component using reversed-phase or normal-phase chromatographic systems, with external standard or area normalization methods, ensuring compliance with specified limits. |
| Related Substances / Impurity Analysis | HPLC Gradient Elution Method | Optimize gradient programs to separate degradation products, process-related impurities, and stereoisomeric impurities for qualitative and quantitative control. |
| Water Content | Karl Fischer Moisture Determination | Accurately determine water content using volumetric or coulometric methods to prevent moisture-induced instability or altered reactivity. |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Detect potentially residual organic solvents from synthesis using headspace or direct injection, in accordance with ICH Q3C guidelines. |
| Loss on Drying | Drying to Constant Weight (at 105°C) | Dry the sample at a specified temperature until constant weight is achieved, measuring total volatile content (including water and low-boiling solvents). |
| Heavy Metals / Elemental Impurities | ICP-MS or Atomic Absorption Spectroscopy (AAS) | Detect harmful elemental impurities such as Pb, As, Cd, and Hg in accordance with ICH Q3D to ensure compliance with safety limits. |
| Specific Optical Rotation | Polarimetry | Measure specific optical rotation at a specified wavelength (typically 589 nm) and concentration, serving as an auxiliary indicator for identity and purity of chiral compounds. |
| pH Value (for solution formulations) | pH Meter Measurement | Measure pH of liquid samples to evaluate acid-base stability and suitability. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting range of solid samples to assist in assessing purity and consistency of crystalline form (if applicable). |
Technical Specifications of 155899-66-4
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146 °C |
| Optical Rotation | +22.0 to +26.0 ° (c=1, in methanol) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 155899-66-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 155899-66-4
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Industrial 155899-66-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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