Hydroxymethyl-7-Aminocephalosporanic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 15690-38-7 |
| Product name | Hydroxymethyl-7-Aminocephalosporanic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Hydroxymethyl-7-Aminocephalosporanic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Hydroxymethyl-7-Aminocephalosporanic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Hydroxymethyl-7-Aminocephalosporanic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key intermediate for semi-synthetic cephalosporin antibiotics, used in the production of cefotiam and cefmenoxime—third-generation cephalosporins | Produced via hydroxymethylation of 7-aminocephalosporanic acid (7-ACA) with formaldehyde under alkaline conditions; alternatively, synthesized by selective hydroxymethylation of 7-ACA obtained from cephalosporin C through enzymatic or chemical deacetylation |
Manufacturing Quality Control of Hydroxymethyl-7-Aminocephalosporanic acid
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | An HPLC system with a reversed-phase C18 column and a UV detector (e.g., 254 nm) is used. The assay is calculated using the external standard method or area normalization method, offering high accuracy and good repeatability. |
| Related Substances (Impurities) | HPLC (Gradient Elution) | Impurity peaks and the main peak are separated by optimizing the gradient elution program of the mobile phase. The total and individual impurity levels are controlled based on relative retention times and peak area limits. |
| Water Content | Karl Fischer Titration | Iodine reacts quantitatively with water in the presence of sulfur dioxide and a base (pyridine/methanol system). The water content is determined by measuring the endpoint visually or potentiometrically, enabling accurate determination of trace moisture. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection is used, with separation on a capillary column and detection by a Flame Ionization Detector (FID). This method quantifies residual organic solvents (e.g., methanol, acetone, ethyl acetate) in accordance with ICH Q3C guidelines. |
| Heavy Metals | ChP General Chapter 0821 (Thioacetamide Method) | After sample digestion, heavy metals react with thioacetamide under weakly acidic conditions to form colored sulfide precipitates. Total heavy metals are quantified using colorimetry or atomic absorption spectrometry. |
| pH Value | pH Meter Measurement | A solution of specified concentration is prepared, and the pH is directly measured using a calibrated pH meter to ensure the acidity or alkalinity meets process and stability requirements. |
| Specific Optical Rotation | Polarimetry | A solution of specified concentration is prepared, and optical rotation is measured at a defined wavelength (typically 589 nm, the sodium D-line) and temperature. Specific optical rotation is calculated to assess optical purity. |
| Loss on Drying | Weight Loss upon Drying | The sample is dried to constant weight under specified conditions (e.g., 105°C, atmospheric or vacuum), and the percentage weight loss is calculated to evaluate the content of volatile substances. |
| Appearance | Visual Inspection | Physical characteristics such as color, crystal form, odor, and solubility are observed. The product should appear as white to off-white crystalline powder, odorless. |
| Melting Point | Capillary Melting Point Method | The melting range from initial to complete melting is determined using a digital melting point apparatus, serving as an auxiliary parameter for identification and purity assessment. |
Technical Specifications of Hydroxymethyl-7-Aminocephalosporanic acid
| Test Item | Specification |
|---|---|
| Appearance | White to yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +110° to +114° (c=1, in water) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Hydroxymethyl-7-Aminocephalosporanic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Hydroxymethyl-7-Aminocephalosporanic acid
Safety Information of Hydroxymethyl-7-Aminocephalosporanic acid
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of Hydroxymethyl-7-Aminocephalosporanic acid
Industrial Hydroxymethyl-7-Aminocephalosporanic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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