Ethyl isonicotinate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1570-45-2 |
| Product name | Ethyl isonicotinate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl isonicotinate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl isonicotinate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl isonicotinate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of the anti-tuberculosis drug isoniazid | Reacted with hydrazine hydrate to form an acyl hydrazone, followed by cyclization and oxidation to produce isoniazid |
| Agrochemicals | Intermediate in the synthesis of herbicides and plant growth regulators | Participates in heterocycle construction reactions to prepare pyridine-ring-containing agrochemical active ingredients |
| Organic Synthesis | Functionalized precursor for pyridine-based compounds | Converted into derivatives such as isonicotinic acid and isonicotinoyl chloride via ester hydrolysis, reduction, or nucleophilic substitution |
Manufacturing Quality Control of Ethyl isonicotinate
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Reverse-phase HPLC is used with a C18 column as the stationary phase. The mobile phase typically consists of methanol-water or acetonitrile-phosphate buffer. The peak area of ethyl isonicotinate is detected by a UV detector (e.g., at 254 nm), and the concentration is calculated using external or internal standard methods. This method offers high sensitivity and specificity. |
| Purity Test | High-Performance Liquid Chromatography (HPLC) | Used to detect related substances in ethyl isonicotinate, such as residual starting materials, degradation products, and intermediates. Impurities are separated from the main component to assess total impurity levels and individual impurity limits, ensuring compliance with pharmacopoeial requirements. |
| Residual Solvent Analysis | Gas Chromatography (GC) | Headspace or direct injection is employed with capillary columns (e.g., DB-624, HP-INNOWAX) and a flame ionization detector (FID) to determine residual organic solvents (e.g., ethanol, ethyl acetate, acetone) from the manufacturing process. The method complies with ICH Q3A/B guidelines. |
| Water Content Determination | Karl Fischer Titration | The Karl Fischer reagent reacts quantitatively with trace amounts of water in the sample. The water content is determined by titration endpoint detection. Suitable for both solid and liquid samples, this is a classical method for determining moisture in pharmaceuticals. |
| pH Measurement | pH Meter Method | The ethyl isonicotinate sample is dissolved in an appropriate amount of water or buffer solution, and the pH of the solution is measured using a calibrated pH meter to ensure it falls within the specified range, reflecting formulation stability and suitability. |
| Melting Point Determination | Micro Melting Point Apparatus | The melting behavior of the sample during heating is observed using a micro melting point apparatus to determine its melting range. This method helps confirm compound identity and purity and is an important technique for physical constant identification. |
| UV-Visible Spectroscopy | UV-Vis Spectrophotometry | The absorption spectrum of ethyl isonicotinate is measured at specific wavelengths (e.g., 260–270 nm) for preliminary identification and supportive assay purposes. It enables rapid screening of abnormal samples. |
| Weight Variation / Mass Balance (for Formulations) | Gravimetric or Volumetric Methods (depending on dosage form) | For tablets, capsules, and other formulations, the actual content per unit dose is determined by weighing or titration to ensure conformity with labeled amounts. Commonly used in finished product release testing. |
Technical Specifications of Ethyl isonicotinate
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.5% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.498–1.504 |
| Relative Density (20°C/25°C) | 1.035–1.045 g/cm³ |
| Odor | Characteristic ester-like odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl isonicotinate
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| Lot/Batch Number | *Required fields | |
NMR Spectra of Ethyl isonicotinate
Packaging of Ethyl isonicotinate
Industrial Ethyl isonicotinate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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