2,4,5-Trifluorobenzyl bromide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 157911-56-3 |
| Product name | 2,4,5-Trifluorobenzyl bromide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2,4,5-Trifluorobenzyl bromide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2,4,5-Trifluorobenzyl bromide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2,4,5-Trifluorobenzyl bromide
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Intermediate for antidiabetic drugs | Serves as a key alkylating agent in the synthesis of tricyclic or side-chain structural motifs of dipeptidyl peptidase-4 (DPP-4) inhibitors, such as sitagliptin. |
| Pharmaceutical Industry | Building block for drug molecules | Introduces the 2,4,5-trifluorobenzyl functional group into target molecules via the high reactivity of benzyl bromide, enabling construction of fluorinated aromatic drug scaffolds with tailored pharmacokinetic properties. |
| Organic Synthesis | Preparation of fluorinated aryl derivatives | Introduces the 2,4,5-trifluorobenzyl group into substrates such as alcohols, amines, or thiols via nucleophilic substitution, for the synthesis of fine chemicals or subsequent complex functional molecules. |
Manufacturing Quality Control of 2,4,5-Trifluorobenzyl bromide
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detector | Quantitative determination based on peak area comparison against a certified reference standard using a non-polar capillary column. |
| Related Substances | Gas Chromatography (GC) with FID detector | Separation and quantification of impurities by retention time and relative response factors; detection limit typically <0.1%. |
| Residual Solvents | Gas Chromatography (GC) with Headspace sampler | Volatile solvent residues are vaporized in sealed vials and quantified via headspace injection onto a polar column. |
| Moisture Content | Karl Fischer Titration (Coulometric mode) | Electrochemical titration where iodine is generated in situ to react stoichiometrically with water; suitable for low-moisture samples (<0.1%). |
| Acid Value | Acid-Base Titration (NaOH standard solution) | Neutralization of acidic impurities (e.g., HBr, hydrolysis products) with standardized sodium hydroxide using phenolphthalein indicator. |
| Halogen Content (Total Bromine) | Oxygen Flask Combustion followed by Potentiometric Titration | Sample combusted in oxygen-filled flask; bromine converted to bromide ion, then titrated with silver nitrate using potentiometric endpoint detection. |
| Heavy Metals (Pb, Cd, Hg, Cr, As) | ICP-MS (Inductively Coupled Plasma Mass Spectrometry) | Sample digested in acid matrix; elements detected and quantified based on isotope-specific mass-to-charge ratios with sub-ppt sensitivity. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against standard white background under controlled lighting conditions. |
| Density | Digital Density Meter (Oscillating U-tube principle) | Measurement of sample density at specified temperature (e.g., 20 C) based on resonant frequency shift of a vibrating U-shaped glass tube filled with sample. |
| Refractive Index | Refractometry (Abbe refractometer) | Determination of refractive index at 20 C using sodium D-line light source; correlates with purity and composition. |
| Boiling Point | Capillary Boiling Point Apparatus (Open Tube method) | Observation of temperature range at which vapor bubbles rise continuously from a capillary immersed in heated liquid bath. |
| Chloride Impurity | Ion Chromatography (IC) with Conductivity Detection | Separation of chloride anions on an anion-exchange column followed by quantitative detection via suppressed conductivity measurement. |
Technical Specifications of 2,4,5-Trifluorobenzyl bromide
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Refractive Index (n20/D) | 1.525–1.535 |
| Relative Density (20°C/25°C) | 1.58–1.62 g/cm³ |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2,4,5-Trifluorobenzyl bromide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2,4,5-Trifluorobenzyl bromide
Packaging of 2,4,5-Trifluorobenzyl bromide
Industrial 2,4,5-Trifluorobenzyl bromide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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