5-chloro-6-methoxypyridin-3-amine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 158387-20-3 |
| Product name | 5-chloro-6-methoxypyridin-3-amine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-chloro-6-methoxypyridin-3-amine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-chloro-6-methoxypyridin-3-amine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-chloro-6-methoxypyridin-3-amine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical & Agrochemical | Agrochemical intermediate | Serves as a key structural unit in the synthesis of pyridine-containing agrochemicals (e.g., fungicides or insecticides), leveraging the reactivity of its chlorine and amino groups for coupling or functionalization. |
| Pharmaceutical & Agrochemical | Pharmaceutical intermediate | Used in synthesizing biologically active drug molecules, commonly incorporated into pyridine-fused ring systems or side-chain structures of kinase inhibitors or receptor antagonists. |
| Organic Synthesis | Substrate for C–N bond formation | Undergoes acylation, alkylation, or diazotization via its amino group to construct complex nitrogen-containing organic frameworks. |
| Organic Synthesis | Substrate for cross-coupling reactions | Undergoes metal-catalyzed coupling reactions (e.g., Suzuki, Buchwald–Hartwig) at the 5-chloro position to introduce aryl, heteroaryl, or amino functionalities. |
| R&D | Chemical reagent | Serves as a building block in drug screening, novel drug discovery, and laboratory-scale methodology development for organic synthesis. |
Manufacturing Quality Control of 5-chloro-6-methoxypyridin-3-amine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification via retention time matching and peak area normalization. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, acetone, ethyl acetate) based on external calibration. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-OES | Multi-element quantification after acid digestion, measuring metals (e.g., Pb, Cd, Ni, Fe) by atomic emission intensity at characteristic wavelengths. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 700-800 C followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid phase transition temperature range using calibrated capillary apparatus per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion via light scattering pattern to calculate volume-based particle size distribution (D10, D50, D90). |
| Bulk Density | ASTM D1895 Method A | Measurement of mass per unit volume for freely settled powder in a calibrated cylinder. |
| Loss on Drying | Thermogravimetric Analysis (TGA) | Weight loss measurement upon heating to 105 C under nitrogen, indicating volatile content including residual moisture and low-boiling impurities. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line (589 nm) to confirm chiral integrity and absence of racemization. |
Technical Specifications of 5-chloro-6-methoxypyridin-3-amine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-chloro-6-methoxypyridin-3-amine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-chloro-6-methoxypyridin-3-amine
Safety Information of 5-chloro-6-methoxypyridin-3-amine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 5-chloro-6-methoxypyridin-3-amine
Industrial 5-chloro-6-methoxypyridin-3-amine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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