China Factory Direct
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| CAS number | 159749-28-7 |
| Product name | AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Synthesis of pharmaceutical intermediates for preparing biologically active azetidinyl compounds | Introduced via N-BOC protection onto the azetidine-2-carboxylic acid molecule, followed by deprotection under specific conditions to yield the target product |
| Organic Synthesis | Key intermediate for constructing complex molecular architectures | Leverages the stability of the BOC (tert-butoxycarbonyl) protecting group to maintain the reactivity of azetidine-2-carboxylic acid throughout multistep syntheses |
| Biochemistry | Study of the biological activity and structure–activity relationships of azetidinyl compounds | Explores mechanisms of action in biological systems through chemical modification and structural analysis |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies impurities (e.g., N-BOC-azetidine, hydrolysis/degradation products) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., THF, ethyl acetate, methanol) by headspace GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration using iodine-based reagent reacting stoichiometrically with water. |
| Heavy Metals | ICP-MS | Quantifies trace metals (e.g., Pb, Cd, Ni, Fe) after acid digestion via inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C followed by weighing of residual residue. |
| Optical Rotation | [a]D Measurement | Determines specific optical rotation using a polarimeter to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Particle Size Distribution | Laser Diffraction | Analyzes particle size distribution in dry or dispersed state using light scattering principles. |
| pH of Aqueous Suspension | pH Meter | Measures hydrogen ion activity in a standardized suspension (e.g., 1% w/v in water) using calibrated pH electrode. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms and specified pathogens by filtration, membrane transfer, and incubation on selective media. |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 125–129°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -5.0 to +5.0° (c=1, in methanol) |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.