(R)-N-BOC-3-AMINOBUTYRIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 159991-23-8 |
| Product name | (R)-N-BOC-3-AMINOBUTYRIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-N-BOC-3-AMINOBUTYRIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-N-BOC-3-AMINOBUTYRIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-N-BOC-3-AMINOBUTYRIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Synthesis of tapentadol, a key chiral intermediate for analgesic drugs | Serves as a chiral building block; the (R)-3-aminobutyric acid moiety is incorporated into the drug scaffold via peptide coupling or reductive amination. |
| Pharmaceutical Chemicals | Synthesis of chiral pharmaceutical intermediates | The Boc protecting group is selectively removed under mild acidic conditions—leveraging its acid lability—to liberate (R)-3-aminobutyric acid for subsequent derivatization. |
| Peptide Chemistry | Synthesis of peptides and peptidomimetics | Used as a non-natural chiral amino acid building block in solid-phase or solution-phase peptide synthesis to modulate peptide conformation or metabolic stability. |
| Research Reagents | Chiral reference standards and analytical controls | Employed in qualitative chiral analysis, development of chiral separation methods, and identification of pharmaceutical impurities. |
Manufacturing Quality Control of (R)-N-BOC-3-AMINOBUTYRIC ACID
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separates (R)- and (S)-enantiomers on a chiral stationary phase and calculates ee from peak area ratio. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., THF, EtOAc, MeOH) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric titration based on iodine-sulfur dioxide redox reaction. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Residual BOC Reagent | GC-MS | Identifies and quantifies residual di-tert-butyl dicarbonate by gas chromatography coupled with mass spectrometric detection. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or foreign matter under controlled white light. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary method per USP <741>. |
| pH (1% w/v aqueous suspension) | pH Meter | Measures hydrogen ion activity in aqueous suspension using calibrated glass electrode pH meter. |
| Loss on Drying | Gravimetric (105 C, 2 h) | Determines volatile content by measuring weight loss after drying under standardized temperature and time conditions. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., deprotected amine, hydrolysis products) using gradient reverse-phase HPLC. |
Technical Specifications of (R)-N-BOC-3-AMINOBUTYRIC ACID
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | +15.5 to +17.5 deg (c=1, in methanol) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 78 to 82 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-N-BOC-3-AMINOBUTYRIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-N-BOC-3-AMINOBUTYRIC ACID
Safety Information of (R)-N-BOC-3-AMINOBUTYRIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-N-BOC-3-AMINOBUTYRIC ACID
Industrial (R)-N-BOC-3-AMINOBUTYRIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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