Isosorbide 5-mononitrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 16051-77-7 |
| Product name | Isosorbide 5-mononitrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Isosorbide 5-mononitrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Isosorbide 5-mononitrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Isosorbide 5-mononitrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Anti-anginal agent | Synthesis of isosorbide-5-mononitrate tablets or injectables |
| Pharmaceuticals | Vasodilator | Preparation of formulations for cardiovascular and cerebrovascular diseases |
| Chemical | Intermediate | Synthesis of other nitrate-based pharmaceuticals or derivatives |
Manufacturing Quality Control of Isosorbide 5-mononitrate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Scan the sample and reference standard under identical conditions, compare characteristic absorption peaks to confirm structural consistency. |
| High-Performance Liquid Chromatography (HPLC) | Compare retention times with those of reference standards to assess chromatographic behavior for identification purposes. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with UV detection (typically around 230 nm), quantifying the main component via external or internal standard method. |
| Related Substances (Impurity Testing) | High-Performance Liquid Chromatography (HPLC) | Separate degradation products and synthetic impurities using gradient or isocratic elution; high sensitivity allows detection of impurities below 0.1%. |
| Residual Solvents | Gas Chromatography (GC) | Determine residual organic solvents (e.g., methanol, ethanol, acetone) used during manufacturing according to ICH guidelines. |
| Drying Loss | Thermogravimetric Analysis or Oven Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight, calculate the percentage loss to assess moisture and volatile components. |
| Residue on Ignition | Residue on Ignition Test Method | Ignite the sample at high temperature and weigh the resulting residue to evaluate inorganic impurity content. |
| Solution Clarity and Color | Visual Color Comparison or UV-Visible Spectrophotometry | Observe whether the solution is clear and free from abnormal color after dissolution, or measure absorbance at specific wavelengths. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine residues of heavy metals such as lead, cadmium, and mercury, ensuring compliance with pharmacopoeial limits. |
| Polymorph Analysis (if applicable) | X-Ray Powder Diffraction (XRD) | Analyze drug polymorphism to ensure consistent crystal form across batches, which affects solubility and stability. |
| Particle Size Distribution (for solid oral dosage form raw materials) | Laser Particle Size Analysis | Evaluate particle size distribution, which influences dissolution rate and bioavailability of the formulation. |
Technical Specifications of Isosorbide 5-mononitrate
| Test Item | Specification |
|---|---|
| Appearance | White or off-white loose mass |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 70-74°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | +160° to +171° (c=1, in methanol) |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Isosorbide 5-mononitrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Isosorbide 5-mononitrate
Packaging of Isosorbide 5-mononitrate
Industrial Isosorbide 5-mononitrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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