tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 161282-57-1 |
| Product name | tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key synthetic intermediate for pyrrolo[2,1-f][1,2,4]triazine derivatives | Serves as a starting material or key intermediate in condensation with hydrazide compounds to construct the triazine ring; subsequently employed in synthesizing the core scaffold of antiviral drugs (e.g., Remdesivir) |
| Pharmaceutical Chemicals | Building block for pyrimido-pyrrole bioactive molecules | Enables introduction of specific side chains or functional groups via nucleophilic addition to the aldehyde group or reductive amination, yielding heterocyclic compounds with potential pharmacological activity |
| Organic Synthesis | Precursor for synthesis of 4-formylpyrrole-1-carboxylic acid tert-butyl ester | Undergoes Vilsmeier–Haack formylation to introduce an aldehyde group at the 4-position of the pyrrole ring, yielding structural isomers |
| Organic Synthesis | Standard reagent for protected derivatives of pyrrole-2-carbaldehyde | Functions as an aldehyde-containing pyrrole building block in complex organic syntheses; the Boc protecting group is selectively removed under acidic conditions after reaction completion to enable subsequent modifications |
Manufacturing Quality Control of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and identification/quantification of structurally related impurities (e.g., unreacted aldehyde, hydrolyzed acid, dimer) using gradient elution and retention time/mass matching. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., THF, DCM, toluene, MeOH) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pd, Ni, Fe, Cu) after microwave-assisted acid digestion, based on atomic mass spectrometry detection. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue post-digestion using optical emission from excited atoms in argon plasma. |
| Optical Rotation | [α]D | Measurement of specific rotation using sodium D-line (589 nm) in specified solvent/concentration to confirm chiral integrity (if applicable; note compound is achiral but may contain chiral impurities). |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change under controlled heating rate per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and homogeneity against established reference standards under controlled lighting. |
| Residual Chlorides | Ion Chromatography (IC) | Quantification of chloride ions after sample dissolution and filtration, using suppressed conductivity detection. |
| Acid Value | Potentiometric Titration | Titration with standardized KOH solution to determine free carboxylic acid content (if deprotected impurity present), monitored by pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using Mie theory to derive volume-based particle size distribution (D10, D50, D90). |
Technical Specifications of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
Safety Information of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate
Industrial tert-Butyl 2-formyl-1H-pyrrole-1-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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