Methyl 4-aminopyridine-3-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 16135-36-7 |
| Product name | Methyl 4-aminopyridine-3-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 4-aminopyridine-3-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 4-aminopyridine-3-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 4-aminopyridine-3-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the anti-tuberculosis drug bedaquiline | Used to construct the pharmacophore scaffold via coupling or nucleophilic substitution with bromoarenes |
| Pharmaceuticals | Synthetic building block for novel protein kinase inhibitor molecules | Applied in amide coupling or preparation of urea derivatives via the amino group |
| Chemical Synthesis | Raw material for synthesizing pyridine-derived functional materials | Employed in the preparation of functional organic molecules via diazotization, coupling, or cyclization reactions |
| Research Reagents | General reagent for constructing heterocyclic compound libraries | Used as a substrate in combinatorial chemistry and high-throughput screening |
Manufacturing Quality Control of Methyl 4-aminopyridine-3-carboxylate
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical form (e.g., white to off-white crystalline powder), and presence of foreign particles or caking. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Using a C18 reversed-phase column with an appropriate mobile phase (e.g., methanol-buffer system) under isocratic or gradient elution, detect the main peak via UV detector (e.g., at 254 nm), and calculate purity based on peak area (typically required ≥98.0%). |
| Assay | HPLC External Standard Method / Non-aqueous Titration | HPLC method: compare peak areas with those of a standard of known concentration to determine content; non-aqueous titration: titrate in glacial acetic acid medium using perchloric acid, with endpoint determined potentiometrically or by indicator, suitable for active pharmaceutical ingredient (API) assay. |
| Related Substances (Impurities) | HPLC Gradient Elution Method | Use a high-sensitivity gradient program to separate potential impurities (e.g., synthesis intermediates, by-products, degradation products); set limits for impurities (e.g., individual impurity ≤0.5%, total impurities ≤1.0%). |
| Loss on Drying | Oven Drying Method (constant weight at 105°C) | Weigh the sample and dry in an oven until constant weight is achieved; calculate percentage weight loss to control moisture and volatile content (typically ≤0.5%). |
| Melting Point | Capillary Melting Point Apparatus | Determine the temperature range from initial melting to complete melting to verify compound polymorphism and purity (literature reference: approximately 140–145°C). |
| Residual Solvents | Gas Chromatography (GC) with Headspace Injection | In accordance with ICH Q3C guidelines, use headspace GC-FID or MS to detect residual organic solvents (e.g., methanol, ethanol, ethyl acetate), ensuring compliance with permissible limits. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) / Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After wet digestion, measure total levels of elements such as lead, arsenic, cadmium, and mercury using AAS or ICP-MS; typically required ≤20 ppm. |
| pH (Solution) | pH Meter Measurement | Dissolve the sample in water to a specified concentration (e.g., 1% w/v), measure using a calibrated pH meter to assess acid-base stability (generally neutral or slightly acidic). |
| Moisture Content | Karl Fischer Titration | Use volumetric or coulometric Karl Fischer titrator to accurately determine trace moisture (especially in hygroscopic samples); control moisture level (e.g., ≤0.5%). |
Technical Specifications of Methyl 4-aminopyridine-3-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.0% (GC) |
| Melting Point | 142–146°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 4-aminopyridine-3-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 4-aminopyridine-3-carboxylate
Safety Information of Methyl 4-aminopyridine-3-carboxylate
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of Methyl 4-aminopyridine-3-carboxylate
Industrial Methyl 4-aminopyridine-3-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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