1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 161491-24-3 |
| Product name | 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as an N-protected piperidone derivative, providing a key scaffold for synthesizing kinase-targeted therapeutics such as JAK and FGFR inhibitors. |
| Pharmaceutical Chemicals | Peptide and Biomimetic Drug Synthesis | Leverages reactivity of the carboxyl group and active methylene to construct piperidine-containing peptidomimetic structures or modify amino acid side chains. |
| Chemical Synthesis | Organic Synthesis Building Block | Undergoes nucleophilic addition, reductive amination, or Grignard reactions at the C-4 carbonyl to construct complex nitrogen-containing heterocycles. |
| Chemical Synthesis | Functional Group Transformation and Modification | Hydrolyzes the methyl ester to the corresponding carboxylic acid under basic conditions, or removes the Boc protecting group, enabling subsequent coupling or cyclization reactions. |
| Research Reagents | Active Molecule Library Construction | Used in combinatorial chemistry or high-throughput screening to generate structurally diverse compound libraries. |
Manufacturing Quality Control of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210–220 nm, comparing peak area to a qualified reference standard. |
| Related Substances | HPLC-UV/DAD | Separates and detects impurities (e.g., hydrolysis products, isomers, residual solvents) via gradient HPLC with diode-array detection for spectral confirmation. |
| Residual Solvents | GC-FID | Quantifies volatile organic solvents (e.g., MTBE, DCM, MeOH, toluene) using headspace GC with flame ionization detection against certified standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Determines trace water by electrochemical titration with iodine generated in situ; based on stoichiometric reaction of water with Karl Fischer reagent. |
| Heavy Metals | ICP-MS | Measures trace elemental impurities (e.g., Pd, Ni, Fe, Cu) after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppt sensitivity. |
| Optical Rotation | [α]D | Measures specific rotation using a digital polarimeter at 20 °C with sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Residual tert-Butyl Alcohol | GC-FID | Quantifies residual t-BuOH (from incomplete esterification or deprotection) via direct injection GC-FID with internal standard calibration. |
| Acid Value | Potentiometric Titration | Determines free carboxylic acid content by titration with standardized NaOH solution using automatic potentiometric endpoint detection. |
| Particle Size Distribution | Laser Diffraction | Measures dry powder particle size distribution by analyzing angular scattering pattern of laser light passed through dispersed sample. |
| Microbial Contamination | Membrane Filtration & Plate Count | Detects aerobic microorganisms by filtration, membrane transfer to agar media, and colony enumeration after incubation per Ph. Eur. 2.6.12. |
Technical Specifications of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
Safety Information of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
Industrial 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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