Methoxycarbonyl-L-tert-leucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 162537-11-3 |
| Product name | Methoxycarbonyl-L-tert-leucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methoxycarbonyl-L-tert-leucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methoxycarbonyl-L-tert-leucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methoxycarbonyl-L-tert-leucine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral building block for synthesizing protease inhibitors (e.g., HIV protease inhibitors) | Participates in coupling reactions as an N-protected amino acid unit in solid-phase or multi-step solution-phase peptide synthesis |
| Pharmaceuticals | Synthesis of non-natural amino acid derivatives to enhance metabolic stability of drug candidates | Substitutes natural amino acids during peptide chain elongation; carboxyl activation and amine coupling achieved using coupling reagents (e.g., HATU/DIPEA) |
| Chemical Synthesis | Chiral auxiliary or intermediate for asymmetric synthesis | Hydrolysis or reductive deprotection yields L-tert-leucine derivatives, applied to construct stereocenters |
| Biotechnology | Structural modification in the development of peptide therapeutics and peptidomimetics | Used as an Fmoc- or Boc-protected amino acid component in solid-phase peptide synthesis (SPPS), with deprotection performed via Pd-catalyzed or acid-mediated methods |
Manufacturing Quality Control of Methoxycarbonyl-L-tert-leucine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Place an appropriate amount of sample on a white background and observe its color, physical state, and presence of foreign particles under natural light or standard illumination. N-Methoxycarbonyl-L-leucine is typically a white to off-white crystalline powder. |
| Identification | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance Proton Spectroscopy (¹H NMR) High-Performance Liquid Chromatography (HPLC) |
- IR: Record the infrared absorption spectrum of the sample and compare characteristic functional group absorption peaks (e.g., carbonyl, amino protecting groups) with reference spectra. - ¹H NMR: Acquire proton NMR spectrum in a deuterated solvent to confirm chemical shifts and integration ratios of protons in the molecular structure. - HPLC: Use specific chromatographic conditions to compare retention times of the sample and reference standard for identity confirmation. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a mobile phase consisting of phosphate buffer and organic solvent (e.g., acetonitrile or methanol), employing gradient or isocratic elution. Detect using a UV detector (typically at 210–220 nm). Calculate impurity levels by area normalization or standard comparison method to control process-related impurities and degradation products. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Under chromatographic conditions similar to those used for related substances—but validated for greater specificity—determine the peak area of the main component using external standard or area normalization method to calculate the content of N-Methoxycarbonyl-L-leucine (typically required ≥98.0%, or as per pharmacopoeia/customer specifications). |
| Specific Optical Rotation | Polarimetry | Dissolve the sample to a defined concentration (e.g., 10 mg/mL in water or methanol), and measure optical rotation using a polarimeter at specified temperature (e.g., 20°C) and wavelength (sodium D line, 589 nm). Calculate specific rotation to confirm L-configuration purity. |
| Water Content | Karl Fischer Titration | Determine water content accurately using volumetric or coulometric Karl Fischer titration. Typically requires ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | In accordance with ICH Q3C guidelines, use headspace or direct injection GC-FID to detect residual organic solvents (e.g., dichloromethane, methanol, ethyl acetate) from synthesis or purification processes, ensuring compliance with permitted limits. |
| Sulfated Ash / Residue on Ignition | Residue on Ignition Test | Ignite the sample at high temperature (typically 700–800°C) until constant weight is achieved, then measure the weight of inorganic residue. Generally limited to ≤0.1%. |
| pH (if applicable) | pH Meter Method | Prepare an aqueous solution of defined concentration (e.g., 1% w/v), and measure pH using a calibrated pH meter as a supplementary quality indicator. |
Technical Specifications of Methoxycarbonyl-L-tert-leucine
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (GC-MS); >=98.0% ee |
| Optical Rotation | -1.5 to -0.5 deg (c=1, in methanol) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 128 to 132 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methoxycarbonyl-L-tert-leucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methoxycarbonyl-L-tert-leucine
Safety Information of Methoxycarbonyl-L-tert-leucine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of Methoxycarbonyl-L-tert-leucine
Industrial Methoxycarbonyl-L-tert-leucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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