China Factory Direct
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| CAS number | 163457-23-6 |
| Product name | 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Synthesizing fluorinated drug intermediates | Introducing fluorine atoms via cyclization and substitution reactions |
| Agrochemical Industry | Serving as a synthetic precursor for pesticide active ingredients | Fluorination followed by functional group modification |
| Chemical R&D | Laboratory reagent for researching novel fluorinated compounds | Multistep organic synthesis |
| Materials Science | Producing fluorinated polymers with specialized properties | Used as a monomer or modifier in polymerization reactions |
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state, and visible foreign particles under natural light or standard illumination. |
| Identification | Nuclear Magnetic Resonance Spectroscopy (NMR) | Confirm compound structure using ¹H NMR and ¹⁹F NMR by comparing characteristic peak positions with literature or reference spectra. |
| Fourier Transform Infrared Spectroscopy (FT-IR) | Determine infrared absorption spectrum and compare functional group-specific absorption peaks (e.g., N–H, C–F, C–N) with reference spectra. | |
| Mass Spectrometry (MS) | Use ESI-MS or EI-MS to detect molecular ion peaks, confirm molecular weight, and fragment ions for structural verification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase C18 column with UV detector (e.g., 210 nm), and quantify active ingredient via external standard or internal standard method. |
| Non-aqueous Titration | Titrate free base form in non-aqueous solvent (e.g., glacial acetic acid) with standardized perchloric acid solution to calculate salt purity. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate impurities using gradient or isocratic elution; quantify by relative retention time with area normalization or self-reference method. |
| Fluorine Content | Ionic Chromatography (IC) or Oxygen Bottle Combustion Method + IC | Completely combust organic material in an oxygen bottle to release fluoride ions, collect in water, then determine fluorine content via ionic chromatography to verify consistency of fluorine content. |
| Chloride (Cl⁻) | Ionic Chromatography (IC) or Silver Nitrate Titration | Dissolve sample and directly analyze chloride ion concentration via IC, or determine total chlorine content using silver nitrate titration. |
| Moisture | Karl Fischer Titration | Use either volumetric or coulometric Karl Fischer titration to accurately determine total water content (bound and free water). |
| Residual Solvents | Gas Chromatography (GC) | Test for common residual solvents such as methanol, ethanol, acetone, dichloromethane, ethyl acetate according to ICH guidelines, using FID detection. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRPD) | Analyze characteristic diffraction peaks of solid-state crystallinity for polymorph control and batch-to-batch consistency evaluation. |
| Particle Size Distribution | Laser Diffraction (LD) | Determine particle size parameters such as D10, D50, and D90 using wet or dry dispersion methods; suitable for pre-formulation studies. |
| Melting Point | Melting Point Apparatus Method | Determine melting temperature range using capillary tube method to assess purity and crystalline consistency. |
| Thermal Stability | Differential Scanning Calorimetry (DSC) | Analyze endothermic/exothermic behavior during heating to identify melting point, polymorphic transitions, or decomposition temperature. |
| Thermogravimetric Analysis (TGA) | Monitor mass changes during heating to evaluate solvent residues, decomposition temperature, and thermal stability. |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 125–130°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.