China Factory Direct
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| CAS number | 164014-95-3 |
| Product name | 1,4-Benzodioxane-6-boronic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing active pharmaceutical ingredients (APIs) containing the benzodioxole moiety, such as candidate 5-HT1A receptor agonist antidepressants | Suzuki-Miyaura cross-coupling reaction |
| Materials Science | Applied in constructing conjugated polymers and organic optoelectronic materials to enhance molecular planarity and charge-carrier transport performance | Palladium-catalyzed cross-coupling of boronic acids with aryl halides to synthesize π-extended functional polymers |
| Agrochemical R&D | Employed as a structural building block in designing and synthesizing novel insecticides or fungicides, introducing stable heterocycles to improve metabolic stability | Transition-metal-catalyzed C–C bond formation for functionalization of the benzodioxole scaffold |
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, condition, and presence of visible impurities under natural light or standard light source. Benzene-1,4-dioxane-6-boric acid is typically a white to off-white crystalline powder. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Use a reverse-phase C18 column with water-organic solvent (such as methanol or acetonitrile) as the mobile phase for gradient or isocratic elution. Quantify the main peak area using a UV detector (usually 220–254 nm), and calculate purity, generally requiring ≥98.0%. |
| Moisture | Karl Fischer Titration | Determine moisture content by reacting with Karl Fischer reagent using coulometric or volumetric methods. Control product moisture content (typically ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with polar or non-polar capillary columns and FID detector to analyze residual organic solvents (e.g., toluene, ethanol, tetrahydrofuran), meeting ICH Q3C limits. |
| Boron Content | Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) or Titration Method | Quantify total boron content via characteristic spectral line intensity using ICP-OES; alternatively, use acid-base titration or mannitol complexometric titration to indirectly determine boric acid group content, verifying structural consistency. |
| Related Substances (Impurities) | HPLC or LC-MS | Use high-sensitivity HPLC method to separate and detect process impurities and degradation products. LC-MS may be used to identify unknown impurity structures if necessary. Individual impurity usually ≤0.5%, total impurities ≤1.0%. |
| Melting Point | Capillary Melting Point Determination | Determine the melting range using a melting point apparatus. Benzene-1,4-dioxane-6-boric acid has a typical melting point of about 215–220°C (decomposition), used to preliminarily assess purity and crystal form consistency. |
| pH Value (Solution) | pH Meter Measurement | Prepare a solution of certain concentration (e.g., 1% w/v) in water, and measure its pH value using a calibrated pH meter to evaluate acidity/alkalinity and potential hydrolysis tendency. |
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.