3-Amino-6-chloro-2-picoline Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 164666-68-6 |
| Product name | 3-Amino-6-chloro-2-picoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 3-Amino-6-chloro-2-picoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Amino-6-chloro-2-picoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Amino-6-chloro-2-picoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a pharmaceutical intermediate in the synthesis of anticancer, antiviral, or central nervous system–targeting drugs | Multi-step organic synthesis, commonly involving amino group protection/deprotection, halogen substitution, or coupling reactions |
| Agrochemicals | Used as an active ingredient or intermediate in the synthesis of novel insecticides or herbicides | Chemical synthesis processes including condensation, cyclization, or functional group transformation |
| Fine Chemicals | Used to prepare specialty dyes, optoelectronic materials, or ligand compounds | Functional group modification, metal-catalyzed coupling, or coordination chemistry synthesis |
Manufacturing Quality Control of 3-Amino-6-chloro-2-picoline
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Assay | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 column with mobile phases such as methanol-water or acetonitrile-phosphate buffer, detected by a UV detector (254–280 nm), and quantified via the external standard method, effectively separating the main component from impurities. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography with UV/DAD Detection (HPLC-UV/DAD) | Employs a gradient elution program to detect process-related impurities (e.g., unreacted starting materials, dechlorination by-products, oxidation products), with qualitative and quantitative analysis performed by comparing retention times and peak areas against reference standards. |
| Chlorine Content | Ion Chromatography (IC) or Oxygen Bomb Combustion-Ion Chromatography | Sample is combusted in an oxygen bomb and absorbed in an alkaline solution, converting chlorine to chloride ions, which are then measured by ion chromatography to verify whether the chlorine content conforms to the theoretical value (theoretical Cl ≈ 25.5%). |
| Water Content | Karl Fischer Titration | Based on the quantitative reaction between water and the iodine-sulfur dioxide-pyridine-methanol system, moisture content is determined via potentiometric or coulometric methods to ensure water content ≤ 0.5% (as required for active pharmaceutical ingredients). |
| Residual Solvents | Gas Chromatography with FID/MS Detection (GC-FID/MS) | Utilizes headspace or direct injection to detect residual solvents regulated by ICH Q3C (e.g., methanol, ethanol, acetonitrile, DMF), quantified using standard calibration curves to ensure compliance with specified limits. |
| Melting Point | Melting Point Apparatus | Determines the melting point range of the pure substance (literature value: approximately 120–125°C) to provide a preliminary assessment of purity and crystalline form consistency. |
| Heavy Metal Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, heavy metals such as lead, cadmium, mercury, and arsenic are quantified to ensure compliance with ICH Q3D limits (e.g., Pb ≤ 10 ppm). |
| Amino Group Content (Indirect) | Acid-Base Titration or HPLC Derivatization Method | Amino groups are derivatized with reagents such as phthalic anhydride followed by HPLC detection, or determined via non-aqueous titration to assist in verifying structural integrity. |
| UV-Visible Absorption Spectrum | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Measures characteristic absorption maxima (λmax ≈ 260–275 nm) in methanol or acetonitrile for rapid identification and approximate concentration estimation, supporting HPLC method validation. |
| Crystal Form Analysis (Optional) | X-Ray Powder Diffraction (XRPD) | If polymorphism is a concern, XRPD is used to compare characteristic diffraction peaks and confirm crystal form consistency, ensuring solubility and stability. |
| Residual Chloride Ions (Water-Soluble) | Ion-Selective Electrode or Ion Chromatography | Detects chloride ions in the water-soluble fraction to evaluate residual inorganic chloride impurities, particularly focusing on the removal of hydrochloride by-products from synthesis. |
Technical Specifications of 3-Amino-6-chloro-2-picoline
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 128.0–132.0 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 3-Amino-6-chloro-2-picoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-Amino-6-chloro-2-picoline
Packaging of 3-Amino-6-chloro-2-picoline
Industrial 3-Amino-6-chloro-2-picoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply