METHYL 5-ACETYLSALICYLATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 16475-90-4 |
| Product name | METHYL 5-ACETYLSALICYLATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for METHYL 5-ACETYLSALICYLATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk METHYL 5-ACETYLSALICYLATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of METHYL 5-ACETYLSALICYLATE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Intermediate in the synthesis of aspirin (acetylsalicylic acid) | Produced via acetylation of methyl salicylate with acetic anhydride under acidic catalysis |
| Fine Fragrance Industry | Precursor or modifier for fragrance ingredients | Acetyl group introduced via transesterification or acetylation to modulate olfactory profile |
| Organic Synthesis | Building block for acetylated aromatic ester moieties in complex molecule synthesis | Used as an electrophile or protecting group in multistep synthetic sequences |
Manufacturing Quality Control of METHYL 5-ACETYLSALICYLATE
| Test Item | Common Testing Method | Method Description |
|---|---|---|
| Appearance and Properties | Visual Inspection, Melting Point Determination | Observe the sample as a white to off-white crystalline powder, measure the melting point range (literature value approximately 120–125 °C), and evaluate whether it meets pharmacopoeia or internal quality standards to exclude impurities or degradation due to moisture. |
| Identification | Infrared Spectroscopy (IR) | Confirm the molecular structure by comparing characteristic absorption peaks in the IR spectrum (e.g., ester carbonyl ~1735 cm⁻¹, acetyl group ~1655 cm⁻¹, phenolic hydroxyl ~3200 cm⁻¹) with standard spectra. |
| Identification | High-Performance Liquid Chromatography (HPLC) | Compare retention times using reference standards under identical chromatographic conditions (e.g., C18 column, methanol-water gradient elution). The main peak of the sample should match the reference standard for qualitative identification. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Quantitative analysis is performed using external standard or internal standard methods with a UV detector (λ=275–280 nm). After optimizing chromatographic conditions, the linear range is typically 10–200 μg/mL with R² > 0.999, ensuring accuracy and precision. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Detect possible degradation impurities such as salicylic acid, acetylsalicylic acid, methyl salicylate using a gradient elution system. Impurity peak area must not exceed specified limits (e.g., ≤0.5%), in compliance with ICH Q3B guidelines. |
| Solvent Residue | Gas Chromatography (GC) | Determine residual organic solvents like ethanol, methanol, ethyl acetate using headspace injection or direct injection. Follow ICH Q3C standards to ensure residue levels are below permitted daily exposure (PDE). |
| Moisture Content | Karl Fischer Titration | Determine trace moisture content using coulometric or volumetric methods. Control moisture within ≤0.5% to prevent hydrolytic degradation that affects stability. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting temperature range of the sample, which should align with literature values (approximately 120–125 °C), to initially assess purity and crystal form consistency. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine heavy metal contents (e.g., lead, cadmium, mercury, arsenic) according to pharmacopoeial methods (e.g., USP <231> or EP 2.4.8). Ensure concentrations remain below limits (e.g., Pb ≤5 ppm) to guarantee safety. |
| Particle Size Distribution (if applicable) | Laser Diffraction Method | For raw materials used in powder formulations, determine particle size distribution (D50) to ensure flowability and consistency in subsequent formulation processes, especially in oral solid dosage forms. |
| Crystallinity Analysis (Optional) | X-ray Powder Diffraction (XRPD) | Confirm the crystalline form to avoid variations in dissolution or stability caused by polymorphism. This is particularly relevant for high-quality API control requirements. |
Technical Specifications of METHYL 5-ACETYLSALICYLATE
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 72-76°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of METHYL 5-ACETYLSALICYLATE
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| Lot/Batch Number | *Required fields | |
NMR Spectra of METHYL 5-ACETYLSALICYLATE
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Industrial METHYL 5-ACETYLSALICYLATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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