4-Chloro-2-hydroxy-3-nitropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 165547-79-5 |
| Product name | 4-Chloro-2-hydroxy-3-nitropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-2-hydroxy-3-nitropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-2-hydroxy-3-nitropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-2-hydroxy-3-nitropyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Used as a key intermediate in the synthesis of novel neonicotinoid insecticides (e.g., flupyradifurone) | Target insecticides are prepared via multi-step reactions including nitration and chlorination; 2-hydroxy-3-nitro-4-chloropyridine serves as a core heterocyclic building block in coupling or substitution reactions |
| Pharmaceuticals | Used to synthesize pyridine derivatives with antibacterial and antiviral activity (early-stage research) | Serves as a starting material for structural modification, undergoing derivatization reactions such as O-alkylation, N-oxidation, or reductive amination to construct candidate drug molecule scaffolds |
Manufacturing Quality Control of 4-Chloro-2-hydroxy-3-nitropyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-DAD | Separation and identification of impurities based on retention time and UV spectral matching; quantified relative to main peak. |
| Residual Solvents | GC-FID | Volatile organic solvents separated by capillary column and detected via flame ionization; quantified using external calibration. |
| Moisture Content | Karl Fischer Titration | Coulometric or volumetric titration with iodine reagent; water reacts stoichiometrically with iodine and sulfur dioxide in pyridine-methanol medium. |
| Heavy Metals (as Pb) | ICP-OES | Multi-element detection after acid digestion; metals emit characteristic wavelengths upon plasma excitation. |
| Chloride Impurity | Ion Chromatography | Separation of anions on ion-exchange column with suppressed conductivity detection; chloride quantified against calibration standards. |
| Nitro Group Content | UV-Vis Spectrophotometry | Quantification based on absorbance of nitroaromatic chromophore in alkaline medium at specific wavelength (e.g., 400 nm). |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary tube method per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Measurement of scattered laser light intensity at multiple angles to calculate particle size distribution based on Mie theory. |
| Residue on Ignition | Gravimetric Analysis | Mass of non-volatile residue remaining after high-temperature ashing (600-800 C) in platinum crucible. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through solution; indicates chiral purity if applicable. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Determination using calibrated glass electrode in 1% w/v suspension in water per USP <791>. |
Technical Specifications of 4-Chloro-2-hydroxy-3-nitropyridine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 128–132°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-2-hydroxy-3-nitropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-2-hydroxy-3-nitropyridine
Safety Information of 4-Chloro-2-hydroxy-3-nitropyridine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-2-hydroxy-3-nitropyridine
Industrial 4-Chloro-2-hydroxy-3-nitropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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