Fmoc-8-amino-3,6-dioxaoctanoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 166108-71-0 |
| Product name | Fmoc-8-amino-3,6-dioxaoctanoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-8-amino-3,6-dioxaoctanoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-8-amino-3,6-dioxaoctanoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-8-amino-3,6-dioxaoctanoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used for introducing the Fmoc protecting group in peptide synthesis to construct soluble or modified peptide chains | Applied in solid-phase peptide synthesis (SPPS) as an Fmoc-protected linker or spacer |
| Biological Conjugation | Employed as a crosslinker or spacer to conjugate biomolecules (e.g., proteins, nucleic acids) with carriers or labels | Activated coupling via carboxyl and amino groups (e.g., EDC/NHS chemistry) |
| Materials Science | Used to synthesize functionalized polymeric materials (e.g., PEG derivatives) for drug delivery or biocompatible coatings | Utilized as a monomer or modification reagent in polymerization reactions, incorporated into polymer chains via ether or amide bonds |
Manufacturing Quality Control of Fmoc-8-amino-3,6-dioxaoctanoic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Content) | High-Performance Liquid Chromatography (HPLC) | Utilizes a reverse-phase C18 column with gradient elution using methanol/water or acetonitrile/water, and detection via a UV detector at 254 nm or 280 nm. Effectively separates the target compound from impurities for quantitative analysis of the main component; purity is typically required to be ≥98%. |
| Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (¹H NMR, ¹³C NMR) | Resolution of molecular structural features through ¹H NMR and ¹³C NMR spectra, such as aromatic ring signals from the Fmoc protecting group, methylene peaks from the ethoxy chain, and carboxylic acid end-group signals, to confirm the correctness of the target compound's structure. |
| Molecular Weight Determination | Mass Spectrometry (MS, ESI-TOF or LC-MS) | Uses electrospray ionization mass spectrometry (ESI-MS) or time-of-flight mass spectrometry (TOF-MS) to obtain the accurate molecular ion peak [M+H]⁺, verifying that the molecular weight matches the theoretical value (calculated value ≈ 376.16). |
| Impurity Analysis | HPLC-MS Coupling Technology | Combines HPLC with mass spectrometric detection to identify and characterize unknown impurities, such as incomplete reaction intermediates, deprotection by-products, or side products, enabling comprehensive impurity profiling. |
| Residual Solvents | Gas Chromatography (GC) | Employs headspace or direct injection with a capillary column (e.g., DB-624, HP-INNOWAX) and a flame ionization detector (FID) to detect residual organic solvents potentially present from synthesis (e.g., acetonitrile, dichloromethane, toluene), in compliance with ICH Q3C limits. |
| Water Content | Karl Fischer Titration | Determines the water content in the sample to ensure it does not adversely affect subsequent reactions (e.g., coupling reactions); water content is typically required to be ≤0.5%. |
| Melting Point Determination | Microscopic Melting Point Apparatus | Measures the melting point range by observing the sample’s melting behavior under controlled heating, serving as a physical property indicator to assist in assessing compound purity and crystalline state. |
Technical Specifications of Fmoc-8-amino-3,6-dioxaoctanoic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 118–122°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -15.0 to -19.0° (c=1, DMF) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-8-amino-3,6-dioxaoctanoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-8-amino-3,6-dioxaoctanoic acid
Safety Information of Fmoc-8-amino-3,6-dioxaoctanoic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-8-amino-3,6-dioxaoctanoic acid
Industrial Fmoc-8-amino-3,6-dioxaoctanoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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