BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 166410-05-5 |
| Product name | BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key intermediate for SGLT2 inhibitor antidiabetic drugs, such as empagliflozin | Chemical synthesis of SGLT2 inhibitor molecules, used to construct bicyclic structures or as a chiral building block |
| Pharmaceutical Industry | Chiral building block in small-molecule drug discovery | Asymmetric synthesis and structural modification/optimization of lead compounds |
| Scientific Research | Synthesis research of peptides and peptidomimetics | Solid-phase or solution-phase peptide synthesis, incorporated into peptide chains as a conformationally restricted amino acid derivative |
Manufacturing Quality Control of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally similar impurities using gradient HPLC-UV against qualified reference standards or threshold-based reporting. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., THF, toluene, ethyl acetate) by headspace GC with flame ionization detection using internal standard calibration. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| Residual Metals (e.g., Pd, Ni, Fe) | ICP-MS | Quantifies trace metal catalyst residues by plasma ionization followed by mass spectrometric detection with isotope dilution or external calibration. |
| Chiral Purity | Chiral HPLC-UV | Evaluates enantiomeric excess using a chiral stationary phase HPLC system with UV detection, comparing retention times and peak areas of enantiomers. |
| Acid Value | Acid-Base Titration | Measures free carboxylic acid content by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| Residual tert-Butyl Alcohol | GC-FID | Quantifies residual t-BuOH by direct injection GC-FID with external calibration curve using an appropriate column. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light against established visual standards. |
| Heavy Metals (Total) | USP <231> Sulfide Precipitation | Semi-quantitative screening for heavy metals (as Pb) by comparison of sulfide-induced color intensity in sample vs lead standard solution. |
| Residual Chlorides | Ion Chromatography | Quantifies chloride ion impurity via suppressed conductivity detection after separation on an anion-exchange column with sodium carbonate eluent. |
Technical Specifications of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.5% (by GC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 98–102 °C |
| Optical Rotation | +10.0 to +11.5 ° (c=1, in CHCl3) |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
Safety Information of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
Industrial BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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