N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 166815-96-9 |
| Product name | N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 166815-96-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 166815-96-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 166815-96-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used to construct nitrogen-containing heterocyclic structures; serves as a key building block in drug molecules, participating in coupling or substitution reactions to introduce the piperidine scaffold |
| Chemical research | Protecting group reagent | BOC (tert-butoxycarbonyl)-protected piperidine derivatives, applied in amino group protection and deprotection strategies to stabilize amino functionality during multistep synthesis |
| Pharmaceutical manufacturing | Antitumor drug intermediate | Involved in the synthesis pathway of targeted therapeutics; enables carbon–carbon or carbon–heteroatom bond formation using methylsulfonyloxy as a leaving group |
Manufacturing Quality Control of 166815-96-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., dichloromethane, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generation in pyridine-free reagent; measures total water by stoichiometric reaction with iodine and sulfur dioxide. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification after acid digestion, using isotopic dilution or external calibration for elements like Pb, Cd, Hg, As. |
| Chloride Impurity | Ion Chromatography | Separation of anions on a high-capacity anion-exchange column with suppressed conductivity detection; quantifies chloride relative to standard curve. |
| Sulfate Impurity | Ion Chromatography | Same platform as chloride; detects sulfate via conductivity after anion exchange and chemical suppression. |
| Residual Tosyl Chloride | HPLC-UV | Specific assay using isocratic or shallow-gradient HPLC-UV to detect unreacted tosyl chloride based on distinct retention and UV absorption. |
| Optical Rotation | [alpha]D Measurement | Polarimetric measurement at 589 nm (Na lamp) to confirm chiral integrity and enantiomeric purity relative to specification limits. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature range over which solid-to-liquid phase change occurs. |
| Appearance | Visual Inspection | Assessment under controlled white light against specified criteria (e.g., white to off-white crystalline powder, free from visible particulates or discoloration). |
| Loss on Drying | Gravimetric Analysis | Weight loss measured after drying under defined vacuum/temperature conditions, reflecting volatile content including residual solvents and moisture. |
Technical Specifications of 166815-96-9
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 166815-96-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 166815-96-9
Packaging of 166815-96-9
Industrial 166815-96-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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