Fmoc-N'-methyltrityl-L-lysine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 167393-62-6 |
| Product name | Fmoc-N'-methyltrityl-L-lysine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-N'-methyltrityl-L-lysine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-N'-methyltrityl-L-lysine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-N'-methyltrityl-L-lysine
| Industry | Application | Process |
|---|---|---|
| Peptide Synthesis | Non-natural amino acid building block for lysine side-chain protection | Used in solid-phase peptide synthesis (SPPS) to incorporate Mtt (4-methyltrityl)-protected lysine residues, enabling selective deprotection for side-chain modification |
| Pharmaceutical R&D | Synthesis of lysine-modified peptide therapeutics or probe molecules | Applied in combinatorial chemistry or targeted drug design to construct peptide structures with specific biological activity or enhanced stability |
| Biochemical Research | Preparation of site-specifically modified proteins or peptides | Used in chemical ligation or semisynthetic approaches to introduce fluorescent labels, biotin, or other functional groups onto lysine side chains |
Manufacturing Quality Control of Fmoc-N'-methyltrityl-L-lysine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe sample color, physical form (e.g., white to off-white powder), and check for caking or foreign matter. It is considered acceptable if it matches the standard description. |
| Purity (HPLC) | High-Performance Liquid Chromatography (HPLC-UV) | Reverse-phase C18 column is used, with acetonitrile/water (containing 0.1% TFA) as the mobile phase under gradient elution. The purity is calculated by peak area normalization at 214 nm or 254 nm. Typically requires ≥98.0% purity. |
| Enantiomeric Purity | Chiral HPLC or Capillary Electrophoresis | Separation of L/D isomers using a chiral stationary phase column. Confirm L-configuration as the major form, with D-isomer content ≤0.5%. |
| Water Content | Karl Fischer Titration | Determine water content in the sample using coulometric or volumetric methods. Generally required ≤1.0%, to avoid affecting subsequent peptide synthesis reactions. |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Head-space or direct injection method to detect residual organic solvents (e.g., DCM, DMF, ethyl acetate) from synthesis or purification processes. Must comply with ICH Q3C limits. |
| Melting Point | Capillary Melting Point Apparatus | Measure the temperature range at which the substance transitions from solid to liquid, used for preliminary assessment of structural consistency (literature reference value: ~120–130°C). |
| Specific Optical Rotation | Automatic Polarimeter | Measure optical rotation [α]D at a specified wavelength (e.g., 589 nm, sodium D-line) and concentration to verify L-amino acid configuration and optical purity. |
| Structure Confirmation | Nuclear Magnetic Resonance (NMR) | ¹H NMR and ¹³C NMR are used to compare characteristic peaks (e.g., Fmoc aromatic ring, Mtt tert-butyl group, lysine side chain), confirming the correct molecular structure. |
| Mass Spectrometry Confirmation | LC-MS or HRMS | Detect the quasi-molecular ion peak [M+H]+ or [M-H]- using ESI or APCI ion source. Match with theoretical molecular weight (Fmoc-Mtt-Lys-OH: C₄₀H₃₈N₂O₄, MW=610.75), with error <5 ppm. |
| Free Amine/Acid Content | Potentiometric or Non-Aqueous Titration | Used to evaluate the integrity of protecting groups. If free amino or carboxyl groups exceed limits, it indicates incomplete protection or partial hydrolysis. |
| Heavy Metals | ICP-MS or Atomic Absorption Spectroscopy | Detect total heavy metals such as Pb, As, Cd, Hg. Typically required ≤20 ppm, meeting pharmacopoeia or specific customer requirements. |
| TLC Spot | Thin Layer Chromatography | Use silica gel plates, developing system such as DCM/MeOH/AcOH. Observe single main spot under UV lamp, with Rf value matching the reference standard and no significant impurity tailing. |
Technical Specifications of Fmoc-N'-methyltrityl-L-lysine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -11.0 to -9.0 deg (c=1, DMF) |
| Melting Point | 178 to 182 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-N'-methyltrityl-L-lysine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-N'-methyltrityl-L-lysine
Safety Information of Fmoc-N'-methyltrityl-L-lysine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-N'-methyltrityl-L-lysine
Industrial Fmoc-N'-methyltrityl-L-lysine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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