(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 167837-43-6 |
| Product name | (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for the anticancer drug palbociclib | Used in the palbociclib synthesis route to construct the pyrido[2,3-d]pyrimidine core via multi-step reactions including amidation and cyclization |
Manufacturing Quality Control of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV/DAD | Separation and detection of impurities (e.g., starting materials, intermediates, degradation products) using gradient HPLC with diode-array detection for spectral confirmation. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify residual solvents (e.g., methanol, ethyl acetate, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Ni, Pd) after acid digestion, using isotopic detection with high sensitivity and low detection limits. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and conductivity detection of chloride ions in aqueous extract, per USP <231> or ICH Q2(R2) validation requirements. |
| Residual Palladium | ICP-MS | Specific quantification of palladium catalyst residue post-hydrogenation, using isotope ¹⁰⁵Pd with internal standard correction. |
| Optical Rotation | [α]D | Measurement of specific rotation using sodium D-line (589 nm) in solution to confirm chiral integrity (though compound is achiral, verifies absence of chiral contaminants). |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory to ensure consistent downstream processing behavior. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) to assess acidic functionality and potential degradation susceptibility. |
| Melting Point | Automated Melting Point Apparatus | Thermal analysis detecting solid–liquid phase transition temperature range, indicating crystallinity and purity per USP <741>. |
Technical Specifications of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.5% (HPLC) |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
Safety Information of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
Industrial (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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