China Factory Direct
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| CAS number | 169048-83-3 |
| Product name | (S)-5-ChloroMethyl-2-oxazolidinone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral building block for synthesizing β-amino acid derivatives and antibiotic intermediates | Produced via chloromethylation of (S)-2-oxazolidinone derivatives; used in subsequent nucleophilic substitution to construct chiral amino frameworks |
| Pharmaceuticals | Optically pure intermediate for synthesizing protease inhibitors and antiviral drugs | Ring-opening aminolysis with amines to generate biologically active oxazolidinone-based drug precursors |
| Chemicals | Chiral auxiliary or ligand precursor for asymmetric catalysis | Functionalized and coordinated to metal catalysts to induce stereoselective reactions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-230 nm. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess determination using a chiral stationary phase with UV detection, comparing retention times and peak areas of (S)- and (R)-enantiomers. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., ethyl acetate, toluene) based on retention time and flame ionization response relative to calibration standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration measuring water via iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, based on atomic emission intensity at characteristic wavelengths. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Residual Catalyst (Pd) | ICP-MS | Ultra-trace quantification of palladium residues after microwave-assisted digestion, based on isotopic mass spectrometry detection. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., hydrolysis products, diastereomers) using gradient reversed-phase HPLC with UV detection. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing solid-to-liquid phase change under controlled heating rate. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using sodium D-line light source in solution, indicating chiral integrity and concentration. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of particulates or foreign matter against established reference standards under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Mass loss measurement after drying under specified temperature/vacuum conditions, indicating volatile content including residual solvents and moisture. |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 78–82°C |
| Optical Rotation | +8.5 to +10.5° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.