BOC-N-Methyl-L-alanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 16948-16-6 |
| Product name | BOC-N-Methyl-L-alanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BOC-N-Methyl-L-alanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BOC-N-Methyl-L-alanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BOC-N-Methyl-L-alanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Amino acid protecting intermediate for solid-phase synthesis of peptide-based therapeutics (e.g., GLP-1 analogs, antimicrobial peptides) | Used as an N-terminally protected α-amino acid monomer in solid-phase peptide synthesis (SPPS); the Boc group is selectively removed under acidic conditions (e.g., TFA/DCM) following Fmoc/tBu strategy coupling |
| Organic Synthesis | Chiral building block for preparing bioactive molecules containing N-methylated alanine motifs | Participates in coupling reactions (e.g., HATU/DIPEA activation), reductive amination, or cyclization to construct heterocyclic scaffolds such as β-lactams and diketopiperazines |
| Biochemical Research | Synthesis of stable isotope-labeled (e.g., ¹³C/¹⁵N) probe peptides for studying protein–ligand interactions | Isotope-labeled Boc-N-methyl-L-alanine is incorporated during liquid-phase or solid-phase synthesis; subsequent enzymatic digestion or mass spectrometry analysis verifies binding sites |
Manufacturing Quality Control of BOC-N-Methyl-L-alanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 200-220 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase, with detection by UV; L-enantiomer content calculated relative to total alanine derivative. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the reaction of iodine with water in a methanol-based reagent. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection, quantifying common solvents (e.g., DMF, THF, ethyl acetate) against calibration standards. |
| Heavy Metals | ICP-MS | Multi-element quantitative analysis after acid digestion, measuring trace metal impurities (Pb, Cd, Hg, As, etc.) at sub-ppb levels. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anion using suppressed conductivity detection with a carbonate eluent. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate anion using suppressed conductivity detection with a carbonate eluent. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., BOC-glycine, N-methyl-L-alanine, di-Boc derivatives) using gradient HPLC-UV. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a digital polarimeter at 20-25 C and sodium D-line (589 nm). |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature range over which solid-to-liquid phase change occurs. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of particulates or discoloration against defined reference standards under controlled lighting. |
| pH of Aqueous Solution | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous solution (e.g., 1% w/v) using a calibrated pH electrode. |
Technical Specifications of BOC-N-Methyl-L-alanine
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 75-79°C |
| Optical Rotation | -32.0 to -29.0 deg (c=1, in CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BOC-N-Methyl-L-alanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BOC-N-Methyl-L-alanine
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Industrial BOC-N-Methyl-L-alanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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