2-Fluoro-5-iodopyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 171197-80-1 |
| Product name | 2-Fluoro-5-iodopyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Fluoro-5-iodopyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Fluoro-5-iodopyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Fluoro-5-iodopyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for anticancer drugs | Used in the synthesis of kinase inhibitors or targeted anticancer drug molecules (e.g., small-molecule inhibitors) via Suzuki cross-coupling to form carbon–carbon bonds |
| Pharmaceuticals | Intermediate for antiviral drugs | Serves as a key building block in the synthesis of antiviral compounds, leveraging its iodine atom in palladium-catalyzed cross-coupling reactions |
| Pharmaceuticals | Synthesis of central nervous system (CNS) drugs | Applied in the synthesis of CNS-active pharmaceuticals via halogen exchange or nucleophilic substitution to introduce specific structural motifs |
| Agrochemicals | Development of insecticides and herbicides | Serves as an intermediate in agrochemical synthesis, enabling construction of fluorinated pyridine-containing active ingredients via nucleophilic substitution |
| Materials Science | Organic optoelectronic materials | Used in synthesizing organic light-emitting diode (OLED) or liquid crystal materials, exploiting its dihalogenated structure for stepwise coupling to extend conjugation |
| Chemical Synthesis | Organic synthesis building block | Applied in Sonogashira coupling to introduce alkynyl groups, or as a substrate for constructing complex pyridine derivatives |
Manufacturing Quality Control of 2-Fluoro-5-iodopyridine
| Detection Item | Common Detection Methods | Method Overview |
|---|---|---|
| Identification | ¹H NMR (Nuclear Magnetic Resonance Hydrogen Spectroscopy) | Confirm molecular structure through characteristic chemical shifts and coupling constants, particularly hydrogen signals for fluorine and iodine substitutions. |
| FT-IR (Fourier Transform Infrared Spectroscopy) | Detect characteristic functional group absorption peaks such as C–F and C–I, assisting in structural confirmation. | |
| Mass Spectrometry (MS) | Confirm molecular weight and elemental composition (including iodine isotopic features) through molecular ion peaks ([M]⁺ or [M+H]⁺) and fragment ions. | |
| Content Determination | HPLC (High-Performance Liquid Chromatography) | Use a reverse-phase C18 column with a UV detector (typically around 254 nm), and quantify the main component using external standard or area normalization methods. |
| Gas Chromatography (GC) | If the compound has good thermal stability, GC-FID or GC-MS can be used for quantitative analysis. | |
| Related Substances/Impurity Testing | HPLC (High-Performance Liquid Chromatography) | Similar to content determination, but optimized separation to detect and quantify process impurities and degradation products. |
| TLC (Thin-Layer Chromatography) | Rapid screening of impurities using an appropriate eluent system and visualization methods (e.g., iodine vapor or UV light observation). | |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with an FID detector, following ICH Q3C guidelines to detect residual organic solvents from synthesis. |
| Moisture | Karl Fischer Titration | Determine moisture content using either volumetric or coulometric methods, suitable for water-sensitive organic compounds. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range of solid samples as an auxiliary indicator of purity and identity. |
| Elemental Analysis (Halogen Content) | Ion Chromatography (IC) or Oxygen Bottle Combustion + Titration | Quantitatively determine fluorine and iodine content to verify molecular composition consistency (less commonly used, mainly for structural confirmation phase). |
| Appearance and Physical Characteristics | Visual Inspection | Observe color, crystalline form, and whether it is clumped, conforming to standard descriptions (usually white to off-white crystalline powder). |
Technical Specifications of 2-Fluoro-5-iodopyridine
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 62–66°C |
| Identification (NMR) | Conforms to reference standard |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Fluoro-5-iodopyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Fluoro-5-iodopyridine
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Industrial 2-Fluoro-5-iodopyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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