TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 177906-48-8 |
| Product name | TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used as a precursor for constructing nitrogen-containing heterocyclic structures in the synthesis of biologically active drug molecules, such as protease inhibitors or receptor antagonists |
| Pharmaceutical R&D | Amine protecting agent | Applied to protect primary amine groups during multistep synthesis using the tert-butoxycarbonyl (Boc) protecting group, with subsequent deprotection under acidic conditions to release free amine |
| Fine chemicals | Chiral building block | Applied in asymmetric synthesis to introduce chiral cyclohexane scaffolds, participating in coupling and reductive amination reactions to prepare target compounds |
| Biopharmaceuticals | Intermediate for antibody–drug conjugate (ADC) synthesis | Used in linker construction to provide a stable amino attachment site for conjugating cytotoxic agents to antibodies |
Manufacturing Quality Control of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at ~210 nm. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and detection of structurally related impurities (e.g., cis-isomer, deprotected amine, hydrolysis products) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID | Quantitative determination of volatile organic solvents (e.g., THF, DMF, toluene, heptane) via headspace gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content based on the stoichiometric reaction of iodine with water in anhydrous methanol/pyridine medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, leveraging high sensitivity and isotopic resolution. |
| Chiral Purity | Chiral HPLC-UV | Enantioselective separation using a chiral stationary phase to confirm absence of racemization and quantify enantiomeric excess of the trans-isomer. |
| Residual tert-Butyl Carbamate (Boc) Group Integrity | 1H NMR Spectroscopy | Verification of intact Boc group via characteristic tert-butyl singlet (~1.4 ppm) and absence of free amine protons (~0.5–5.0 ppm broad). |
| Particle Size Distribution | Laser Diffraction | Measurement of dry or wet dispersed particle size via angular scattering pattern analysis of laser light. |
| Melting Point | DSC or Capillary Melting Point Apparatus | Thermal transition detection identifying onset and range of solid-to-liquid phase change, confirming crystallinity and batch consistency. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Determination of inorganic ash content by high-temperature incineration followed by precise weighing of residual inorganic material. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a standardized suspension (e.g., 1% w/v in water) to assess potential acidic/basic degradation products. |
| Optical Rotation | [α]D Measurement | Quantification of specific rotation at 589 nm to confirm stereochemical integrity and batch-to-batch consistency of the chiral trans-cyclohexylamine scaffold. |
Technical Specifications of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
Packaging of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
Industrial TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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