China Factory Direct
|
|
| CAS number | 177966-63-1 |
| Product name | FMOC-D-4-Nitrophe |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeReagent GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Pharmaceutical intermediate | Used as a chiral building block for synthesizing peptide-based drugs |
| Biochemistry | Reagent for peptide synthesis | Introduces the D-4-nitrophenylalanine residue in Fmoc-based solid-phase peptide synthesis |
| Organic synthesis | Raw material for chiral catalysts or ligands | Participates in asymmetric synthesis reactions to construct chiral centers |
| Analytical chemistry | Reference standard or control substance | Applied in chiral compound identification and quantification by HPLC or LC-MS analysis |
| Materials science | Synthesis of functional materials | Used to prepare chiral materials with specific optical or electrochemical properties |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 268 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., FMOC-D-Phe, nitrophenyl derivatives) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., DMF, DCM, methanol) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Optical Purity (Enantiomeric Excess) | Chiral HPLC-UV | Separation of D- and L-enantiomers on a chiral stationary phase and calculation of enantiomeric excess from peak areas. |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic ash content by high-temperature incineration followed by weighing of residual residue. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in suspension using angular scattering intensity of laser light. |
| pH (1% w/v aqueous solution) | Potentiometric Titration | Measurement of hydrogen ion activity using calibrated pH electrode in aqueous dispersion. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, observed visually under controlled heating. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under standardized white light and against specified reference standards. |
| Loss on Drying | Thermogravimetric Analysis | Weight loss measurement upon heating under defined conditions (e.g., 105 C, 2 h) to determine volatile content. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral compound in solution at specified concentration and wavelength (589 nm). |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | +27° to +31° (c=1, DMF) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
|
|
|
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.